New combo shows promise for Tough-to-Treat myeloma

NCT ID NCT01745640

Completed Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a combination of pomalidomide and dexamethasone in 63 patients with multiple myeloma that had returned or stopped responding to treatment, and who had specific high-risk genetic changes. The goal was to see how well the drugs controlled the disease and what side effects occurred. The results help doctors understand if this treatment can slow cancer growth in this difficult-to-treat group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pomalidomide and dexamethasone
What this could lead to: If successful, this combination could offer a treatment option for multiple myeloma patients with high-risk genetic features who have few alternatives.
What could go wrong: This is a small, early-phase study (63 patients) without a comparison group. Results may not apply to all patients, and side effects like low blood counts or infections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chromosome 17p deletion plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

CHRU POITIERS-Hôpital Jean Bernard

Poitiers, 86021, France
CHRU RENNES 1, Hôpital Sud

Rennes, 35056, France
CHRU RENNES 2, Hôpital Pontchaillou

Rennes, 35033, France
CHRU, Hôpital A.Michallon

Grenoble, 38043, France
CHRU, Hôpital Purpan

Toulouse, 31059, France
CHRU, Hôpitaux de Brabois

Vandœuvre-lès-Nancy, 54511, France
CHRU, Hôtel Dieu

Nantes, 44035, France
CHRU- Hôpital Bretonneau

Tours, 37044, France
CHRU-Hôpital Sud Amiens

Amiens, 80054, France
CHU - Hôpital St Antoine,

Paris, 75571, France
CHU DIJON, Hôpital d'Enfants

Dijon, 21000, France
Centre Hospitalier Lyon Sud -1

Pierre-Bénite, 69495, France
Centre Hospitalier Lyon Sud -2

Pierre-Bénite, 69495, France
Centre hospitalier départemental La Roche sur Yon

La Roche-sur-Yon, 85025, France
Chru Caen

Caen, 14033, France
Chru Lille

Lille, 59037, France
Hôpital Haut-Leveque

Pessac, 33604, France
Hôpital Robert Debré, CHU Reims

Reims, 51092, France
Hôpital Saint-Louis

Paris, 75475, France
Institut Paoli Calmette,

Marseille, 13273, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.