Polycystic ovary syndrome

This study tests a device that uses heat to ablate (destroy) a small part of the ovary in women with polycystic ovary syndrome (PCOS) who have trouble getting pregnant. The goal is to restore ovulation without needing daily medication. About 195 women will be randomly assigned to…

This study compares two common fertility treatments—letrozole alone versus clomiphene citrate plus tamoxifen—in 240 women with infertility due to ovulation problems. The goal is to see which approach leads to more ovulations and pregnancies. Participants will be monitored with ul…

This study tests whether adding myoinositol or pioglitazone to metformin improves pregnancy rates in women with PCOS undergoing ICSI (a type of IVF). 150 women will take one of three drug regimens for one month before the procedure. Researchers will track fertilization, pregnancy…

This study tests whether adding a myo-inositol supplement to the standard fertility drug letrozole helps women with polycystic ovary syndrome (PCOS) achieve pregnancy. About 168 women will receive either the supplement or a placebo alongside letrozole for up to 5 treatment cycles…

This study aimed to test semaglutide in women with polycystic ovary syndrome (PCOS) to see if it helps with weight and treatment adherence. It was designed for women aged 18-45 with a BMI over 30. However, the study was withdrawn before enrolling any participants, so no results a…

This study tests whether a specially designed mobile app can help women with Polycystic Ovary Syndrome (PCOS) improve their eating and exercise habits. About 92 women will either use the app or receive a pamphlet with advice. The goal is to see if the app leads to better weight m…

This study looks at whether using a CPAP machine to treat obstructive sleep apnea can help improve insulin resistance and hormone levels in women with Polycystic Ovary Syndrome (PCOS). Researchers will measure changes in fat production, testosterone, and insulin in 20 women aged …

This study tests whether a DASH diet or a very low-carbohydrate diet is better at improving blood sugar control and body weight in adults with polycystic ovary syndrome (PCOS). 223 participants will follow one of the two diets for 12 months, with support from psychological skills…

This study tests whether a 25-week supervised aerobic exercise program, added to usual medication and diet, can improve hormone levels, menstrual regularity, and quality of life in 60 women with insulin-resistant PCOS. Participants are randomly assigned to either the exercise gro…

This study looks at two ways of taking the drug letrozole to help women with PCOS ovulate and get pregnant. One group takes 5 mg daily for 10 days, the other takes 10 mg daily for 5 days. Researchers will track follicle growth and ovulation to see which schedule is more effective…

This study aimed to see if metformin or birth control pills were more satisfying for treating PCOS in women aged 40-49. It planned to use a quality-of-life questionnaire to measure patient satisfaction. However, the study was withdrawn before any participants were enrolled, so no…

This study tests whether combining senobi exercises with aerobic workouts can help women with polycystic ovary syndrome (PCOS) lose weight, feel less tired, and improve their quality of life. Thirty-two women aged 18 to 35 with PCOS will be split into two groups: one doing both s…

This study compares two dietary approaches—a standard Mediterranean diet and a fertility-optimized version called FertilOMed—against usual care in 36 women with PCOS. Over 12 weeks, researchers will track changes in hormones, metabolism, weight, and quality of life to see if a ta…

This study looks at whether teenagers and young adults with Polycystic Ovary Syndrome (PCOS) have more fat in their liver than those without PCOS. Researchers will use advanced imaging and tests to measure liver fat, insulin resistance, and cholesterol problems in 80 participants…

This pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…

This study is testing whether a Mediterranean-style low-carb diet that reduces calories can lower insulin and testosterone levels in overweight or obese women with insulin resistance. Eight premenopausal women aged 21-45 will follow the diet to lose about 5% of their body weight.…

This study aims to learn more about blood sugar patterns in women with Polycystic Ovary Syndrome (PCOS) using a continuous glucose monitor (CGM). Researchers will compare women with and without PCOS to see how their blood sugar differs in daily life. They will also test whether w…

This study aims to understand how blood sugar levels change in women with Polycystic Ovarian Syndrome (PCOS). Participants will wear a continuous glucose monitor on their arm for certain periods over 6 months, have two blood draws, and complete a questionnaire. The goal is to gat…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…

This study looks at whether certain gene variations influence how well the diabetes drug metformin works in women with polycystic ovary syndrome (PCOS). Researchers will give 100 women with PCOS metformin for 24 weeks and measure changes in insulin resistance, weight, and cholest…