New hope for PCOS: drug combo may improve IVF outcomes

NCT ID NCT07604779

Ongoing Disease control Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding myoinositol or pioglitazone to metformin improves pregnancy rates in women with PCOS undergoing ICSI (a type of IVF). 150 women will take one of three drug regimens for one month before the procedure. Researchers will track fertilization, pregnancy, and miscarriage rates to find the best approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin, myoinositol, and pioglitazone
What this could lead to: If successful, this could identify a better pre-treatment regimen to improve fertilization and pregnancy rates in women with PCOS undergoing ICSI.
What could go wrong: This is a small, early-phase trial with no blinding, so results may not be definitive. Side effects from the drugs are possible, and the study may not lead to a standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYCYSTIC OVARIAN SYNDROME (PCOS)

Contacts and locations

Locations

Beni-Suef University Hospital

Banī Suwayf, Beni Suweif Governorate, 62521, Egypt

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