Zapping ovaries: could a quick procedure replace daily pills for PCOS infertility?

NCT ID NCT06206746

Ongoing Disease control Sponsor: May Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 4 times

Summary

This study tests a device that uses heat to ablate (destroy) a small part of the ovary in women with polycystic ovary syndrome (PCOS) who have trouble getting pregnant. The goal is to restore ovulation without needing daily medication. About 195 women will be randomly assigned to receive the procedure or a sham, and researchers will track ovulation rates and side effects over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: May Health System (radiofrequency ablation device)
What this could lead to: If successful, this could offer a one-time, drug-free option to help women with PCOS ovulate and become pregnant naturally.
What could go wrong: This is an early pivotal trial with 195 participants, so results may not apply to all. The procedure carries risks like infection or ovarian damage, and it may not restore ovulation in everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

female infertility polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERTILITY, FEMALE POLYCYSTIC OVARY SYNDROME

Contacts and locations

Locations

Baylor Scott & White Medical Center

Temple, Texas, 76508, United States
Cypress Medical Research Center

Wichita, Kansas, 67226, United States
HRC Fertility - Encino

Encino, California, 91436, United States
Johns Hopkins Fertility Center

Lutherville, Maryland, 21093, United States
Penn Fertility Care

Philadelphia, Pennsylvania, 19104, United States
Penn State College of Medicine

Hershey, Pennsylvania, 17003, United States
Prisma Health - Upstate

Greenville, South Carolina, 29605, United States
Reach Fertility

Charlotte, North Carolina, 28207, United States
SIU School of Medicine, Reproductive Endocrinology & Infertility Center

Springfield, Illinois, 62702, United States
The IVF Center

Winter Park, Florida, 32792, United States
UCSF Center for Reproductive Health

San Francisco, California, 94158, United States
UNC Fertility

Raleigh, North Carolina, 27617, United States
UT Health San Antonio

San Antonio, Texas, 78229, United States
UW Health Generations Fertility Care

Middleton, Wisconsin, 53562, United States
University of Iowa Health Care

Iowa City, Iowa, 52240, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester, Strong Fertility Center

Rochester, New York, 14623, United States
University of South Florida

Tampa, Florida, 33606, United States
Washington University Fertility and Reproductive Medicine Center

St Louis, Missouri, 63110, United States

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