Weight fluctuations may worsen PCOS symptoms, new study investigates
NCT ID NCT06545721
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how losing weight and then regaining it (weight cycling) affects hormone levels and insulin resistance in women with Polycystic Ovary Syndrome (PCOS). Researchers will follow 425 women with PCOS, some at normal weight and some with overweight or obesity, as they try to lose weight through a high-protein diet. The goal is to see how different amounts of weight loss (from less than 2% to 10% or more) improve PCOS symptoms, and whether weight regain reverses those benefits. A smaller part of the study will test if a personalized diet based on insulin resistance works better than a standard diet.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
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The condition terms exactly as the trial's registrant entered them.
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Peking Union Medical College Hospital
RECRUITINGBeijing, Beijing Municipality, 100730, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••