Weight fluctuations may worsen PCOS symptoms, new study investigates

This study looks at how losing weight and then regaining it (weight cycling) affects hormone levels and insulin resistance in women with Polycystic Ovary Syndrome (PCOS). Researchers will follow 425 women with PCOS, some at normal weight and some with overweight or obesity, as they try to lose weight through a high-protein diet. The goal is to see how different amounts of weight loss (from less than 2% to 10% or more) improve PCOS symptoms, and whether weight regain reverses those benefits. A smaller part of the study will test if a personalized diet based on insulin resistance works better than a standard diet.