Could a diabetes drug boost fertility in PCOS? new trial tests combo therapy

NCT ID NCT07462065

Recruiting now Disease control Sponsor: PAEC General Hospital, Islamabad Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 4 trial tests whether adding pioglitazone (a diabetes drug) to standard clomiphene citrate improves ovarian stimulation and pregnancy rates in 62 infertile women with polycystic ovary syndrome (PCOS). Participants are randomly assigned to receive either pioglitazone or a placebo alongside clomiphene, and follicle growth is tracked via ultrasound. The study aims to see if the combination leads to more mature eggs and higher pregnancy rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: clomiphene citrate and pioglitazone
What this could lead to: If successful, this could show that adding pioglitazone to clomiphene improves ovarian stimulation and pregnancy rates in women with PCOS.
What could go wrong: This is a small Phase 4 trial with only 62 participants, so results may not apply to all women. Side effects like swelling, fluid retention, and weight gain are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERTILITY TREATMENT PREGNANCY RATES

Contacts and locations

Locations

Pakistan Atomic Energy Commission Hospital
RECRUITING

Islamabad, Federal, 44000, Pakistan

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