Which hormone protocol yields healthier embryos for PCOS patients?
NCT ID NCT05326087
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two common ovarian stimulation protocols—PPOS (using a progesterone-like drug) and GnRH antagonist—in women with polycystic ovary syndrome (PCOS) who are undergoing preimplantation genetic testing (PGT-A). The goal is to see which method results in more genetically normal embryos. About 204 women aged 20-37 with PCOS will be randomly assigned to one of the two groups, and the main outcome is the rate of healthy (euploid) embryos.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Medroxyprogesterone acetate (MPA) and Cetrorelix (GnRH antagonist)
- What this could lead to
- If this trial succeeds, it could show that one stimulation method leads to more genetically normal embryos, potentially improving IVF success for women with PCOS.
- What could go wrong
- This is a phase 3 trial, but it only compares two existing methods—neither is new. The results may not apply to all women with PCOS, and the primary outcome is embryo health, not live birth.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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