Which hormone protocol yields healthier embryos for PCOS patients?
NCT ID NCT05326087
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two common ovarian stimulation protocols—PPOS (using a progesterone-like drug) and GnRH antagonist—in women with polycystic ovary syndrome (PCOS) who are undergoing preimplantation genetic testing (PGT-A). The goal is to see which method results in more genetically normal embryos. About 204 women aged 20-37 with PCOS will be randomly assigned to one of the two groups, and the main outcome is the rate of healthy (euploid) embryos.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Medroxyprogesterone acetate (MPA) and Cetrorelix (GnRH antagonist)
What this could lead to
If this trial succeeds, it could show that one stimulation method leads to more genetically normal embryos, potentially improving IVF success for women with PCOS.
What could go wrong
This is a phase 3 trial, but it only compares two existing methods—neither is new. The results may not apply to all women with PCOS, and the primary outcome is embryo health, not live birth.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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