Could diabetes meds help women with PCOS get pregnant?

NCT ID NCT07589075

Completed Disease control Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding dapagliflozin (a diabetes drug) or metformin to the standard ovulation drug letrozole helps women with PCOS ovulate and become pregnant more often. 500 women aged 20-40 with PCOS and infertility took part. The goal was to see if these combinations improve ovulation and pregnancy rates compared to letrozole alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dapagliflozin and metformin (as add-on to letrozole)
What this could lead to: If successful, this approach could offer a new way to help women with PCOS ovulate and become pregnant more effectively.
What could go wrong: This is a completed phase 4 trial, but results are not yet published. The benefits may be modest, and side effects like urinary infections or gastrointestinal issues are possible with these drugs.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INDUCTION OF OVULATION

Contacts and locations

Locations

Gynecology and Reproductive department in Beni-Suef University Hospital

Banī Suwayf, 62517, Egypt

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