Can a gut microbiome transplant boost fertility in PCOS?

This trial investigates whether taking capsules containing freeze-dried fecal matter from healthy donors—known as fecal microbiota transplantation (FMT)—can improve pregnancy outcomes and metabolic health in overweight or obese women with polycystic ovary syndrome (PCOS) who are undergoing frozen embryo transfer. The study will first test safety and early signs of effectiveness in a small group, then compare FMT against a control in a larger randomized phase. Participants will take the capsules for two 6-day courses, alongside standard lifestyle and dietary guidance.