PCOS (POLYCYSTIC OVARY SYNDROME)

This study tests a new weekly injection called HEC88473 in 30 women with polycystic ovary syndrome (PCOS). The drug targets two pathways to improve hormone levels and menstrual cycles. Researchers will track changes in free androgen index and menstrual regularity over 24 weeks.

This study tests a physical activity program called ActiveGirls in 40 girls ages 8-12 who are at higher risk for PCOS and insulin resistance. Some girls get health coaching plus text messages, while others get only texts. Researchers will see if the program is acceptable and if i…

This study looks at whether a 6-month diet low in sugar and high in fiber can improve insulin resistance, hormone levels, and menstrual cycles in 56 women with PCOS living in remote Yunnan, China. The diet is adapted to local eating habits to make it easier to follow. The goal is…

This study tests whether two natural supplements, myo-Inositol and Dioscorea Villosa, can help teenagers aged 14-19 with irregular menstrual cycles, including those with PCOS. The goal is to see if these supplements can make periods more regular. The trial is small, with only 20 …

This study compares taking the fertility drug letrozole for 10 days versus the usual 5 days in women with PCOS who want to get pregnant. About 20 women aged 18-40 will be randomly assigned to one of the two groups. The goal is to see if the longer treatment leads to more ovulatio…

This study tests whether online group education and lifestyle coaching can improve quality of life and health markers in women with PCOS and obesity. Forty non-pregnant women aged 18-49 will be assigned to either the virtual program or usual care. Researchers will measure changes…

This 12-week study at Ohio State University tests whether a keto diet or a mixed diet with ketone supplements can help women with PCOS have regular periods and improve hormone balance. About 40 women aged 18-40 will be randomly assigned to one of two groups. The goal is to see if…

This study looks at inflammation markers in the blood of women with PCOS, with or without insulin resistance, and compares them to women without PCOS. The goal is to understand how inflammation relates to metabolic problems in PCOS. Participants will have blood tests but no treat…

This study is measuring three proteins (kisspeptin, ghrelin, and zonulin) in the blood of women with and without PCOS to see if they can serve as early warning signs of insulin resistance. Researchers will compare levels among three groups: women with PCOS and insulin resistance,…

This pilot study looks at gene activity in cumulus cells (cells that surround eggs) from 10 women with PCOS undergoing a special lab-based egg maturation technique called CAPA-IVM. Researchers want to see if these gene patterns can predict which eggs will develop into healthy emb…