Shanghai Changzheng Hospital

This study tests a combination of two drugs, anlotinib and sintilimab, as a first treatment for people with advanced colorectal cancer that has spread but not to the liver. The goal is to see if this drug pair can shrink tumors and control the disease without standard chemotherap…

This early-stage trial tests a new mRNA drug called MTS109 in 15 people with moderate to severe autoimmune diseases like lupus, scleroderma, and Sjogren's syndrome. The main goal is to see if the treatment is safe and tolerable. Researchers will also check if it helps control the…

This study tests a new drug called IBI311 against standard hormone therapy for people with active moderate to severe thyroid eye disease (TAO). TAO is an autoimmune condition that can cause bulging eyes, double vision, and even blindness. The trial will enroll 64 participants to …

This study tests a drug called IBI311 in 50 people with inactive moderate-to-severe thyroid eye disease, a condition that can cause bulging eyes and double vision. IBI311 blocks a protein that drives inflammation and tissue growth around the eyes. The goal is to see if it improve…

This study tests whether rifaximin-α, an antibiotic that works in the gut, can reduce liver fat in people with metabolic fatty liver disease (MASLD). About 60 adults will take the drug or follow standard diet and exercise advice for 24 weeks. The goal is to see if the drug safely…

This early study tests whether a single injection of special stem cells (hiSCs) into the knee is safe and can ease symptoms of rheumatoid arthritis. About 15 adults with active knee arthritis will take part. The goal is to see if the treatment reduces pain, swelling, and improves…

This study tests a drug called tetuzumab (IBI311) in people with moderate to severe thyroid eye disease (TAO) who did not get enough help from steroids. The drug blocks a protein that fuels inflammation and tissue swelling behind the eyes. About 96 adults will receive the treatme…

This early-stage study is testing whether the antibiotic rifaximin can safely reduce fat buildup in the liver for people with metabolic-associated fatty liver disease (MAFLD). About 40 adults will take rifaximin pills three times a day for up to 48 weeks while following a healthy…

This study looks at whether giving pancreatic enzymes to people with chronic pancreatitis and poor digestion can improve blood sugar control. Researchers will track changes in glucose levels and digestive hormones in 80 adults over time. The goal is to better understand how the p…

This study follows about 4,000 adults from Shanghai communities to see how heart, kidney, and metabolic diseases develop over time. Researchers will compare current health data with information collected between 2016 and 2017. The goal is to understand how risk factors change and…

This study uses a non-invasive eye-tracking device to measure how Thyroid-Associated Ophthalmopathy (TAO) affects eye movement and visual attention. Researchers will compare 100 participants—both patients with TAO and healthy volunteers—as they watch images on a screen. The goal …

This study looks at whether the amount of iron in a person's tears is related to how bad their dry eye disease is. Researchers will compare tear samples from 52 people with dry eyes and healthy eyes. The goal is to find a new way to diagnose and understand dry eye better.