Stem cell shot for arthritis knees: hope or hype?

NCT ID NCT06947746

Recruiting now Disease control Sponsor: Shanghai Changzheng Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study is testing whether a single injection of special stem cells (hiSCs) into the knee joint is safe and can reduce pain and swelling in people with rheumatoid arthritis. Only 15 adults with active knee arthritis will take part. The main goal is to check for side effects and see if there are any signs of improvement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hiSCs (stem cells made from reprogrammed human cells)
What this could lead to: If it works, this could point toward a new way to ease knee pain and swelling in rheumatoid arthritis without needing daily medication.
What could go wrong: This is a very early, tiny trial with only 15 people and no comparison group. The stem cells might not help, could cause side effects, or the benefit might be small and short-lived.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS (RA)

Contacts and locations

Locations

Shanghai ChangZheng hospital
RECRUITING

Shanghai, 200003, China

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