Can a common gout drug help unclog leg arteries?

NCT ID NCT06212271

Completed Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the leg arteries of people with peripheral artery disease (PAD). Twenty-four adults with PAD received either colchicine or a placebo. Researchers used special scans and blood tests to measure changes in artery inflammation and also asked participants about their walking ability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: colchicine
What this could lead to: If it works, this could point toward a way to reduce artery inflammation and improve walking ability in people with peripheral artery disease.
What could go wrong: This is a very small, early-phase trial with only 24 participants. The results may not apply to everyone, and colchicine can cause side effects like stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for PERIPHERAL ARTERY DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atherosclerosis Inflammation peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL ARTERY DISEASE

Contacts and locations

Locations

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.