PERIPHERAL ARTERY DISEASE

This study tests a special balloon designed to open up hardened leg arteries in people with peripheral artery disease. About 58 participants with moderate to severe calcium buildup will receive the balloon treatment. Researchers will check if the balloon successfully widens the a…

This study compares a special balloon coated with sirolimus (a drug that prevents re-blockage) to a standard balloon for opening blocked arteries below the knee in people with peripheral artery disease. About 230 participants will be randomly assigned to one of the two treatments…

This study compares two types of drug-coated balloons used to open blocked arteries in the leg. About 478 people with peripheral artery disease will receive either a sirolimus-coated balloon or a paclitaxel-coated balloon. The goal is to see if the sirolimus balloon works as well…

This study is tracking how well a drug-coated balloon called SELUTION SLR works in real-world patients with peripheral artery disease (PAD). The balloon is inflated in narrowed leg arteries to open them and release a drug that helps keep them open. Researchers are following 723 p…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study tests whether using a far red light device on the legs for 10 minutes twice a day can improve walking distance in people with peripheral artery disease (PAD). The trial involves 32 adults aged 50 and older with PAD. Participants use the light at home for four months, a…

This study tests whether wearing inflatable leg cuffs (intermittent pneumatic compression) for six months can improve walking distance in people with peripheral artery disease (PAD). Some participants also combine the cuffs with walking exercise. The goal is to see if the cuffs h…

This early study tests whether a combination of arginine, tetrahydrobiopterin, and vitamin C can boost nitric oxide levels in the blood and help people with peripheral artery disease walk longer without pain. Ten participants will take the therapy and be monitored for changes in …

This study tests whether a 12-week telehealth-supervised exercise program can improve walking ability and quality of life in veterans with peripheral artery disease (PAD). Participants exercise three times a week at a location of their choice. The study measures walking distance,…

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study tests a new wireless sensor that is injected under the skin to measure oxygen levels in the legs of people with peripheral artery disease (PAD). The sensor tracks how oxygen changes when blood flow is altered by a pressure cuff or changing position. Researchers want to…

This study was designed to find better ways to manage heart disease in veterans with severe peripheral artery disease (poor leg blood flow) who had leg surgery. It planned to track major heart problems like heart attacks or heart-related death. However, the study was withdrawn be…