Diabetes drug metformin tested to boost walking in artery disease patients
NCT ID NCT03054519
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether taking metformin daily for six months can improve how far people with peripheral artery disease can walk in six minutes. 203 participants were randomly assigned to receive metformin or a placebo. The goal was to see if this common diabetes drug could ease leg pain and improve mobility.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin
What this could lead to
If it works, this could offer a simple, cheap way to help people with peripheral artery disease walk farther and feel better.
What could go wrong
This is a completed Phase 3 trial, but metformin is already used for diabetes; its benefit for PAD may be modest or not clinically meaningful.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Northwestern University
Chicago, Illinois, 60611, United States
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Ochsner Medical Center
New Orleans, Louisiana, 70121, United States
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Tulane University
New Orleans, Louisiana, 70112, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Florida
Gainesville, Florida, 32610, United States