Could Pain-Free exercise help PAD patients walk better?

NCT ID NCT05712395

Recruiting now Symptom relief Sponsor: University of Oklahoma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new, pain-free exercise program for people with peripheral artery disease (PAD), which causes leg pain when walking. Researchers will compare it to standard painful exercise over 3 months in 100 adults aged 40 and older. The goal is to see if the pain-free program improves walking time and calf muscle oxygen levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Non-Ischemic Exercise (NICE) program
What this could lead to: If it works, this could offer a more comfortable exercise option for people with PAD, helping them walk farther without pain.
What could go wrong: This is a small, early-stage study (100 people) comparing two exercise programs. The new program may not be more effective than standard exercise, and results may not apply to all PAD patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intermittent vascular claudication peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLAUDICATION PERIPHERAL ARTERY DISEASE

Contacts and locations

Locations

O'Donoghue Research Building, University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73117, United States

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