Laser zaps leg artery blockages in new trial

NCT ID NCT05916950

Recruiting now Disease control Sponsor: Philips Clinical & Medical Affairs Global Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new laser device called the Thor system to treat blockages in the leg arteries caused by peripheral artery disease (PAD). About 155 adults with PAD will receive the laser treatment and be followed for a year. The main goals are to see if the device is safe and if it successfully opens the blocked arteries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Thor laser atherectomy system (a device that uses laser energy to remove calcium blockages in leg arteries)
What this could lead to: If successful, this could offer a new, less invasive way to treat blocked leg arteries in people with peripheral artery disease, potentially improving blood flow and reducing symptoms.
What could go wrong: This is an early-stage study with only 155 participants, so results may not apply to everyone. Risks include artery damage, bleeding, or the blockage returning.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAD PERIPHERAL ARTERY CALCIFICATION PERIPHERAL ARTERY DISEASE PERIPHERAL ARTERY STENOSIS

Contacts and locations

Locations

Ascension St. John
RECRUITING

Bartlesville, Oklahoma, 74006, United States
Atlantic Medical Imaging of New jersey
RECRUITING

Vineland, New Jersey, 08360, United States
Baylor, Scott & White, The Heart Hospital
RECRUITING

Plano, Texas, 75093, United States
Cardiovascular Institute of the South
RECRUITING

Houma, Louisiana, 70360, United States
Cardiovascular Institute of the South
RECRUITING

Lafayette, Louisiana, 70503, United States
Deborah Heart and Lung Center
RECRUITING

Browns Mills, New Jersey, 08015, United States
Guardian Research Organization
RECRUITING

Winter Park, Florida, 32792, United States
Heart and Vascular Institute of Central Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Henry Ford St John Hospital
RECRUITING

Detroit, Michigan, 22201, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Lankenau Institute for Medical Research
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Manatee Memorial Hospital
RECRUITING

Bradenton, Florida, 34205, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
New York Presbyterian Hospital/Columbia University Irving Medical Center
RECRUITING

New York, New York, 10029, United States
Premier Cardiovascular Institute
RECRUITING

Fairborn, Ohio, 45324, United States
Rocky Mountain Regional VA Medical Center
RECRUITING

Aurora, Colorado, 80045, United States
Sentara Health Research Center
RECRUITING

Norfolk, Virginia, 23507, United States
Southcoast Hospitals/Charlton Memorial Hospital
RECRUITING

Fall River, Massachusetts, 02720, United States
St. Helena Hospital
RECRUITING

St. Helena, California, 94574, United States
Tallahassee Research Institute
RECRUITING

Tallahassee, Florida, 32308, United States
The Miriam Hospital
RECRUITING

Providence, Rhode Island, 02905, United States
The Vascular Care Group
RECRUITING

Portland, Maine, 04106, United States
UPMC
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Vascular Breakthroughs
RECRUITING

Leominster, Massachusetts, 04153, United States
Vascular Institute of Chattanooga
RECRUITING

Chattanooga, Tennessee, 37421, United States
Vascular Institute of the Midwest
RECRUITING

Davenport, Iowa, 52807, United States
Vascular Solutions of North Carolina
RECRUITING

Cary, North Carolina, 27518, United States

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