Milton S. Hershey Medical Center

This study tests if a simple program of mailed information and a couple of phone calls can help seniors with arthritis start using a free gym membership they already have through their insurance. Researchers want to see if using this benefit, called SilverSneakers, leads to bette…

This study is testing whether giving people with type 2 diabetes vouchers to buy fruits and vegetables helps them manage their condition. It will involve 120 low-income adults with diabetes and compare different approaches to using these food vouchers. The goal is to see if this …

This study is testing a new, unapproved pill called silmitasertib, given alongside standard chemotherapy drugs. It aims to find a safe and effective dose for children and young adults under 30 whose solid tumors (like neuroblastoma or sarcoma) have come back or stopped responding…

This study is testing whether an intensive monitoring program helps people with cirrhosis and fluid buildup stay healthier after leaving the hospital. Patients receive a digital scale, educational materials, weekly check-in calls, and early follow-up appointments. Researchers wil…

This study is testing whether using an automated insulin pump system or a special education program can help adults with type 1 diabetes regain their natural ability to feel the symptoms of dangerously low blood sugar (hypoglycemia). About 324 participants who have lost this warn…

This study is testing a new oral drug, AMXT 1501, combined with an existing drug called DFMO, for children and young adults with aggressive cancers that have come back or didn't respond to standard treatments. The first part aims to find a safe dose, and the second part will comp…

This study is testing a new therapy approach for children ages 4-12 who show problematic sexual behaviors. Researchers want to see if their Phase-Based Treatment works better than standard care. The study will involve 42 children and their caregivers to compare the two approaches…

This study is testing a daily herbal supplement called INM176, made from Angelica Gigas Nakai root, in men with a history of prostate cancer. The main goals are to find a safe dose and see if taking the supplement for six months can lower or stop the rise of PSA, a blood marker l…

This study is testing whether nicotine pouches can help smokers reduce their cigarette use by at least 75% over 16 weeks. Researchers will compare different nicotine strengths and flavors to see which works best for cutting down smoking. The study involves 375 smokers who want to…

This study aims to find the most effective 'dose' of exercise for treating fatty liver disease (NAFLD/NASH), which has no approved drug cure. Researchers will test different exercise amounts in 45 sedentary adults with the disease to see which best reduces liver fat. The goal is …

This study is testing a new, low-cost sweat sensor that sticks to the skin to diagnose cystic fibrosis. Researchers will compare this new device to the current standard sweat test in 30 adults, including both people with CF and healthy volunteers. The goal is to create a simpler,…

This study is testing if a short video featuring local cancer survivors sharing their stories can encourage more parents to get the HPV vaccine for their children. Researchers will show the video to 200 parents of unvaccinated 9-12 year olds before a doctor's visit. The main goal…

This study is testing a new type of therapy for anorexia nervosa that aims to reduce anxiety about eating and weight gain. It combines real-life practice, like eating feared foods, with mental exercises. The researchers want to see if this approach is practical, acceptable to pat…

This small pilot study is testing whether a single, brief mindfulness session before surgery can help people with endometriosis. The goal is to see if learning mindfulness techniques is practical for patients and if it might help them cope with stress and pain after their operati…

This study is developing and testing an AI-powered chatbot designed to help teens and young adults with eating disorders. The chatbot provides exposure therapy exercises to help reduce anxiety about weight gain. Participants will use the chatbot as an extra tool during their firs…

This small pilot study is testing a virtual therapy program for teens with anorexia nervosa. The goal is to help participants reduce their intense anxiety about weight gain and eating through guided, weekly online sessions. Sixteen teens will receive 20 free therapy sessions, whi…

This study aims to find the best treatment for different types of insomnia. Researchers are comparing a behavioral therapy program (CBT-I) with a low-dose medication (trazodone) in 600 adults with chronic insomnia. The goal is to see which treatment works better for people who sl…

This small pilot study is testing whether playing music for patients during common back pain injections can help them feel less anxious and experience less pain. Researchers will compare anxiety and pain scores between a group that listens to music and a group that does not. The …

This study is testing a new program where college students are trained to provide therapy to high schoolers in rural Pennsylvania. The goal is to see if this approach can effectively reduce symptoms of depression, anxiety, and stress in teens who often have limited access to ment…

This study is testing two different approaches to help teens and young adults with eating disorders manage their anxiety about weight gain. Researchers are comparing 'open weighing,' where patients see and discuss their weight, with 'blind weighing,' where they avoid focusing on …

This study is testing whether a 12-week yoga program can help reduce pain for women with endometriosis. Researchers are recruiting 30 women with moderate pain to participate in online yoga sessions. The goal is to see if yoga, as a complementary therapy, improves pain scores and …

This study aims to find brain activity patterns that can predict which children with ADHD and significant aggression or irritability will improve with stimulant medication. Researchers will enroll 136 children, ages 8-12, to have their stimulant dose optimized and then test their…

This study aims to understand why some people's blood pressure rises when they stand up, a condition called orthostatic hypertension. Researchers will recruit 30 participants to test a theory that leg veins trigger a nerve reflex that increases blood pressure. They will use gentl…

This study is testing an online training program called 'iLook Out for Child Abuse' to see if it helps childcare workers better understand their legal duty to report suspected child abuse and neglect. It measures if the training improves their knowledge, changes their attitudes, …

This study aims to understand how opioid withdrawal affects a newborn's brain and find better ways to predict which babies will have more severe symptoms. Researchers will collect saliva from 50 opioid-exposed newborns to look for tiny molecules that might act as warning signs. T…

This study is trying to understand if a parent's ability to manage their own emotions influences how effective a standard parenting course is for children with ADHD. Researchers will enroll 65 parents of children aged 5-12 with ADHD and some oppositional behaviors. Parents will c…

This study aims to understand why and how often diabetes develops after a person has acute pancreatitis. Researchers will follow 800 people for three years, performing regular blood sugar tests and health surveys. The goal is to learn the underlying causes and identify who is mos…

This study aims to understand a basic body reflex where stretched veins signal nerves to adjust blood pressure. Researchers will test if a common painkiller (ketorolac) blocks this signal and use MRI scans to see if it changes vein size. They are recruiting 18 healthy adults aged…

This study aims to find out if a continuous glucose monitor (CGM) can predict who will develop diabetes or pre-diabetes after having acute pancreatitis. Researchers will follow 800 people who recently had pancreatitis, using the monitor and other tests over three years to spot ea…

This study is testing two conversation-based tools to help people from underserved communities talk about and plan for their end-of-life care wishes. Researchers will work through trusted community networks to see if these tools are better than just handing out standard planning …

This early-stage study aims to understand if an experimental drug called angiotensin-(1-7) can improve heart and blood vessel health in people who have both obesity and high blood pressure. Researchers will give the drug or a placebo (saltwater) to 52 participants through an IV a…

This early-stage study aims to understand if a hormone called angiotensin-(1-7) can improve heart and blood vessel health in healthy older adults. Researchers will give 26 participants aged 65-80 an intravenous infusion of the hormone or a placebo saline solution and measure effe…