New pill combo offers hope for kids with relapsed cancers
NCT ID NCT06465199
First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times
Summary
This study tests two oral drugs, eflornithine (DFMO) and AMXT 1501, in children and young adults up to age 26 with certain cancers that have come back or not responded to treatment. The cancers include neuroblastoma, brain tumors, and sarcomas. The goal is to find a safe dose and see if the combination helps keep the cancer from growing longer than DFMO alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Arnold Palmer Hospital for Children
RECRUITINGOrlando, Florida, 32806, United States
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Cardinal Glennon Children's Medical Center
RECRUITINGSt Louis, Missouri, 63104, United States
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Children's Medical Center
RECRUITINGDallas, Texas, 75235, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Kansas, 64108, United States
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Connecticut Children's Hospital
RECRUITINGHartford, Connecticut, 06106, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Kapiolani Medical Center for Women and Children
RECRUITINGHonolulu, Hawaii, 96813, United States
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Monroe Carrell Jr. Children's Hospital at Vanderbilt
RECRUITINGNashville, Tennessee, 37232, United States
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Nicklaus Children's Hospital
RECRUITINGMiami, Florida, 33155, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITINGHershey, Pennsylvania, 17033, United States
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St. Joseph's Children's Hospital
RECRUITINGTampa, Florida, 33614, United States
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University of Alabama/Children's of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
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University of Florida
RECRUITINGGainesville, Florida, 32611, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a radioactive 'Smart Bomb' take down resistant childhood cancers?