Nicotine pouches tested as a way to help smokers quit

NCT ID NCT06043362

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether nicotine pouches can help smokers reduce their cigarette use. 375 smokers who smoke at least 5 cigarettes a day will be given different strengths and flavors of nicotine pouches to use for 16 weeks. Researchers will measure changes in cigarette smoking and exposure to harmful chemicals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

nicotine pouches (0 mg, 3 mg, or 6 mg nicotine, in smooth or wintergreen flavor)

What this could lead to

If it works, this could show that nicotine pouches are a safer alternative for smokers who want to cut down on cigarettes.

What could go wrong

This is an early-stage study with no placebo group for comparison. The pouches still deliver nicotine, which is addictive, and long-term health effects are unknown.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Penn State College of Medicine

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••