Nicotine pouches tested as a way to help smokers quit

NCT ID NCT06043362

Recruiting now Disease control Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether nicotine pouches can help smokers reduce their cigarette use. 375 smokers who smoke at least 5 cigarettes a day will be given different strengths and flavors of nicotine pouches to use for 16 weeks. Researchers will measure changes in cigarette smoking and exposure to harmful chemicals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine pouches (0 mg, 3 mg, or 6 mg nicotine, in smooth or wintergreen flavor)
What this could lead to: If it works, this could show that nicotine pouches are a safer alternative for smokers who want to cut down on cigarettes.
What could go wrong: This is an early-stage study with no placebo group for comparison. The pouches still deliver nicotine, which is addictive, and long-term health effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOBACCO DEPENDENCE

Contacts and locations

Locations

Penn State College of Medicine
RECRUITING

Hershey, Pennsylvania, 17033, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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