New hope for young cancer patients: experimental drug targets hard-to-treat ewing sarcoma

NCT ID NCT05734066

Recruiting now Disease control Sponsor: Jazz Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called lurbinectedin in children and young adults (ages 2 to 30) with Ewing sarcoma that has returned or not responded to prior treatments. The first part finds the safest dose, and the second part checks if the drug shrinks tumors. About 60 participants will take part, and the goal is to control the disease, not cure it.

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Conditions

The condition(s) this trial relates to.

Ewing sarcoma neoplasm sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EWING SARCOMA REFRACTORY EWING SARCOMA RELAPSED EWING SARCOMA

Contacts and locations

Locations

Children's Health Dallas
RECRUITING

Dallas, Texas, 75235, United States
Children's Healthcare of Atlanta at Arthur M. Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital of Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Johns Hopkins All Children's Hospital
RECRUITING

St. Petersburg, Florida, 33701, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21238, United States
Lucile Packard Children's Hospital
RECRUITING

Palo Alto, California, 94304, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
St. Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States
The Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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