Immune booster: could donor NK cells help kids beat sarcoma?
NCT ID NCT05634369
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding specially trained donor immune cells (NK cells) to standard chemotherapy can help children and young adults with sarcomas that have returned or not responded to treatment. About 50 participants aged 2 to 40 will receive up to 8 cycles of chemo plus NK cell infusions. The goal is to see if this combination is safe and improves how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TGFβ imprinted, ex vivo expanded universal donor NK cells
What this could lead to
If successful, this could offer a new treatment option for children with sarcomas that have come back or not responded to standard therapy.
What could go wrong
This is an early-phase trial (Phase 1/2) with only 50 participants, so results may not apply broadly. There are risks from chemotherapy and potential immune reactions from the donor NK cells.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Children's Hospital of Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Duke Children's Hospital/Duke Health
RECRUITINGDurham, North Carolina, 27710, United States
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Johns Hopkins All Children's Hospital
RECRUITINGSt. Petersburg, Florida, 33701, United States
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Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28203, United States
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Montefiore Medical Center
RECRUITINGThe Bronx, New York, 10467, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Nemours Jacksonville
RECRUITINGJacksonville, Florida, 32207, United States
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Roswell Park Comprehensive Cancer Center
RECRUITINGBuffalo, New York, 14263, United States
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Stanford University
RECRUITINGPalo Alto, California, 94304, United States
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UT Southwestern
RECRUITINGDallas, Texas, 75390, United States
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University of Alabama
RECRUITINGSouth Birmingham, Alabama, 35233, United States
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University of Florida
RECRUITINGGainesville, Florida, 32610, United States
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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University of North Carolina
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Washington University/St Louis Childrens
RECRUITINGSt Louis, Missouri, 63110, United States
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