Immune booster: could donor NK cells help kids beat sarcoma?

NCT ID NCT05634369

Recruiting now Disease control Sponsor: Nationwide Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding specially trained donor immune cells (NK cells) to standard chemotherapy can help children and young adults with sarcomas that have returned or not responded to treatment. About 50 participants aged 2 to 40 will receive up to 8 cycles of chemo plus NK cell infusions. The goal is to see if this combination is safe and improves how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TGFβ imprinted, ex vivo expanded universal donor NK cells
What this could lead to: If successful, this could offer a new treatment option for children with sarcomas that have come back or not responded to standard therapy.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 50 participants, so results may not apply broadly. There are risks from chemotherapy and potential immune reactions from the donor NK cells.

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Conditions

The condition(s) this trial relates to.

Ewing sarcoma osteosarcoma Recurrence rhabdomyosarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC SARCOMA, REFRACTORY PEDIATRIC SARCOMA, RELAPSED

Contacts and locations

Locations

Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202, United States
Children's Hospital of Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Duke Children's Hospital/Duke Health
RECRUITING

Durham, North Carolina, 27710, United States
Johns Hopkins All Children's Hospital
RECRUITING

St. Petersburg, Florida, 33701, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Nemours Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14263, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
UT Southwestern
RECRUITING

Dallas, Texas, 75390, United States
University of Alabama
RECRUITING

South Birmingham, Alabama, 35233, United States
University of Florida
RECRUITING

Gainesville, Florida, 32610, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University/St Louis Childrens
RECRUITING

St Louis, Missouri, 63110, United States

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