New combo therapy targets tough sarcomas in kids and adults

NCT ID NCT06156410

First seen Nov 16, 2025 · Last updated May 13, 2026 · Updated 14 times

Summary

This early-phase trial tests whether combining the drug cabozantinib with high-dose ifosfamide is safe and effective for children and adults with sarcomas that have returned or not responded to standard treatment. About 30 participants with bone or soft tissue sarcomas will receive the drug combination. The main goal is to find the best dose with acceptable side effects.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's Hospital Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

    Contact

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.