New stem cell approach aims to fight tough childhood cancers

NCT ID NCT06625190

Recruiting now Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests a special stem cell transplant for children, teens, and young adults (ages 6 months to 25 years) with solid tumors that have come back or not responded to treatment. The transplant uses cells from a donor, with certain immune cells removed to reduce side effects, and is combined with a drug called zoledronic acid to boost the immune system's ability to fight the cancer. The goal is to see if this approach is safe and can improve survival rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stem cell transplant (depleted of certain immune cells) plus zoledronic acid
What this could lead to: If this works, it could offer a new treatment option for young patients with hard-to-treat solid tumors that have come back or not responded to other therapies.
What could go wrong: This is an early-phase trial with only 27 participants, so results are preliminary. The transplant carries risks like graft-versus-host disease and infection, and it may not improve survival.

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Conditions

The condition(s) this trial relates to.

alveolar soft part sarcoma chordoma clear cell sarcoma desmoplastic small round cell tumor epithelioid sarcoma Ewing sarcoma myoepithelial tumor nerve sheath neoplasm neuroblastoma osteosarcoma rhabdoid tumor rhabdomyosarcoma sarcoma synovial sarcoma Wilms tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALVEOLAR SOFT PART SARCOMA CHORDOMA CLEAR CELL SARCOMA DESMOPLASTIC SMALL ROUND CELL TUMOR EPITHELIOID SARCOMA EWING SARCOMA MYOEPITHELIAL TUMOR NEUROBLASTOMA OSTEOSARCOMA PERIPHERAL NERVE SHEATH TUMORS RHABDOID TUMOR RHABDOMYOSARCOMA SYNOVIAL SARCOMA WILMS TUMOR

New stem cell approach aims to fight tough childhood cancers

Summary

What this could mean

Get notified about this study

Conditions

As listed by the trial registrant

Contacts and locations

Locations

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