New drug trial hopes to shrink tumors in kids with Hard-to-Treat cancers

NCT ID NCT06395103

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This study tests a drug called zilovertamab vedotin in children and young adults whose blood cancers (like certain leukemias and lymphomas) or solid tumors (neuroblastoma, Ewing sarcoma) have come back or not responded to treatment. The goal is to see if the drug is safe and can shrink or eliminate the cancer. About 90 participants will receive the drug, and researchers will monitor side effects and how well the cancer responds.

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia Burkitt lymphoma diffuse large B-cell lymphoma Ewing sarcoma neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA BURKITT LYMPHOMA DIFFUSE LARGE B-CELL LYMPHOMA EWING SARCOMA NEUROBLASTOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aghia Sophia Children's Hospital-First Department of Pediatrics, National and Kapodistrian Universi ( Site 1797)
RECRUITING

Athens, Attica, 115 27, Greece
Alberta Children's Hospital ( Site 1227)
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
Ankara Bilkent Şehir Hastanesi ( Site 1962)
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Asan Medical Center-Pediatrics - Pedicatric Oncology ( Site 1973)
RECRUITING

Seoul, 05505, South Korea
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 1102)
RECRUITING

Marseille, Provence-Alpes-Côte d'Azur Region, 13005, France
Birmingham Children's Hospital-Oncology/Haematology ( Site 1349)
RECRUITING

Birmingham, England, B4 6NH, United Kingdom
CENTRE LEON BERARD-IHOPE (pediatrric oncology) ( Site 1100)
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69373, France
CHU de Bordeaux. Hopital Pellegrin ( Site 1105)
RECRUITING

Bordeaux, Aquitaine, 33076, France
Centre Hospitalier Universitaire de Nantes - Hôpital Femme-Enfant-Adolescent Chu De Nantes ( Site 1104)
RECRUITING

Nantes, Loire-Atlantique, 44093, France
Charité Campus Virchow-Klinikum-Klinik für Pädiatrie mit Schwerpunkt Hämatologie und Onkologie ( Site 1143)
RECRUITING

Berlin, 13353, Germany
Children's Hospital Colorado-Center for Cancer and Blood Disorders ( Site 1016)
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles ( Site 1006)
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia (CHOP) ( Site 1021)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Mercy Hospital ( Site 1024)
RECRUITING

Kansas City, Missouri, 64108, United States
Clinica de la Costa S.A.S.-Clinical Research Oncology & Hematology -Pediatric ( Site 1924)
RECRUITING

Barranquilla, Atlántico, 080020, Colombia
Corewell Health ( Site 1001)
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dana-Farber Cancer Institute ( Site 1013)
RECRUITING

Boston, Massachusetts, 02215, United States
Detska nemocnice FN Brno ( Site 1388)
RECRUITING

Brno, Brno-mesto, 613 00, Czechia
Ege Universitesi Hastanesi ( Site 1963)
RECRUITING

Bornova, İzmir, 35100, Turkey (Türkiye)
Fakultni nemocnice v Motole-Klinika detske hematologie a onkologie ( Site 1387)
RECRUITING

Prague, Praha 5, 150 00, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori-Pediatric Oncology ( Site 1552)
RECRUITING

Milan, Lombardy, 20133, Italy
Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site 1267)
RECRUITING

São José do Rio Preto, São Paulo, 15090000, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1264)
RECRUITING

Barretos, São Paulo, 14784400, Brazil
Gustave Roussy ( Site 1103)
RECRUITING

Villejuif, Île-de-France Region, 94805, France
Hacettepe Universite Hastaneleri ( Site 1961)
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Hospital Carlos Van Buren ( Site 1880)
RECRUITING

Valparaíso, Valparaiso, 2341131, Chile
Hospital Clínico Regional Dr. Guillermo Grant Benavente ( Site 1881)
RECRUITING

Concepción, Biobio, 4070038, Chile
Hospital Erasto Gaertner-CEPEP - Pesquisa Clínica ( Site 1268)
COMPLETED

Curitiba, Paraná, 81520-060, Brazil
Hospital Infantil Universitario Niño Jesús-Servicio de Onco-Hematología Pediátrica ( Site 1715)
RECRUITING

Madrid, Madrid, Comunidad de, 28009, Spain
Hospital Luis Calvo Mackenna ( Site 1879)
RECRUITING

Santiago, Region M. de Santiago, 7500539, Chile
Hospital Pablo Tobon Uribe ( Site 1923)
RECRUITING

Medellín, Antioquia, 050034, Colombia
Hospital Sant Joan de Déu-Pediatric Oncology Department ( Site 1717)
RECRUITING

Esplugas de Llobregat, Barcelona, 08950, Spain
Hospital Universitari Vall d'Hebron-Servei de Hematologia i Oncologia Pediatrica ( Site 1716)
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario y Politecnico La Fe de Valencia ( Site 1718)
RECRUITING

Valencia, Valenciana, Comunitat, 46026, Spain
Hospital de Clinicas de Porto Alegre ( Site 1265)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
IMAT S.A.S ( Site 1921)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
Intermountain - Primary Children's Hospital ( Site 1014)
RECRUITING

Salt Lake City, Utah, 84113, United States
Johns Hopkins All Children's Hospital ( Site 1025)
RECRUITING

St. Petersburg, Florida, 33701, United States
McGill University Health Centre-Pediatric HematologyOncology ( Site 1223)
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan Kettering Cancer Center ( Site 1010)
RECRUITING

New York, New York, 10065, United States
Narodny ustav detskych chorob ( Site 1592)
RECRUITING

Bratislava, Bratislava Region, 831 01, Slovakia
National Taiwan University Hospital ( Site 1983)
RECRUITING

Taipei, 10002, Taiwan
New York Medical College ( Site 1023)
RECRUITING

Valhalla, New York, 10595, United States
Oregon Health and Science University ( Site 1004)
RECRUITING

Portland, Oregon, 97239, United States
Ospedale Infantile Regina Margherita-S.C. Oncoematologia Pediatrica ( Site 1551)
RECRUITING

Torino, 10126, Italy
Ospedale Pediatrico Bambino Gesù IRCCS-Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica ( Site 1553)
RECRUITING

Rome, Roma, 00165, Italy
Prinses Maxima Centrum voor Kinderoncologie ( Site 1510)
RECRUITING

Utrecht, 3584 CS, Netherlands
Queensland Children's Hospital-Oncology & Haematology ( Site 1996)
RECRUITING

Brisbane, Queensland, 4101, Australia
Rambam Health Care Campus-Pediatric Hemato-Oncology ( Site 1674)
RECRUITING

Haifa, 3109601, Israel
Rigshospitalet-Department of paediatrics and adolescent medicine, Section of Paed haem-onc ( Site 1467)
RECRUITING

Copenhagen, Capital Region, DK-2100, Denmark
Royal Children's Hospital-Children's Cancer Centre ( Site 1994)
RECRUITING

Melbourne, Victoria, 3052, Australia
Royal Marsden Hospital (Sutton)-Drug Development Unit ( Site 1347)
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
Royal Victoria Infirmary-Great North Children's Hospital ( Site 1348)
RECRUITING

Newcastle upon Tyne, England, NE1 4PL, United Kingdom
Rutgers Cancer Institute of New Jersey ( Site 1008)
RECRUITING

New Brunswick, New Jersey, 08903, United States
Sahlgrenska Universitetssjukhuset ( Site 1634)
RECRUITING

Gothenburg, Västra Götaland County, 416 85, Sweden
Sanford Children's Hospital-Sanford Children's Specialty Clinic ( Site 1015)
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 1003)
RECRUITING

Fargo, North Dakota, 58102, United States
Semmelweis Egyetem ( Site 1838)
RECRUITING

Budapest, 1085, Hungary
Seoul National University Hospital-Pediatrics ( Site 1972)
RECRUITING

Seoul, 03080, South Korea
Sheba Medical Center ( Site 1675)
RECRUITING

Ramat Gan, 5265601, Israel
Sydney Children's Hospital ( Site 1997)
RECRUITING

Randwick, New South Wales, 2031, Australia
The Hospital for Sick Children ( Site 1225)
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
UZ Gent ( Site 1428)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Universitaetsklinikum Koeln. Klinik und Poliklinik ( Site 1145)
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
Universitaetsklinikum Tuebingen ( Site 1142)
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
University College London Hospital ( Site 1350)
RECRUITING

London, London, City of, NW1 2PG, United Kingdom
University Hospital of Wales ( Site 1346)
RECRUITING

Cardiff, CF14 4XW, United Kingdom
University of Iowa-Holden Comprehensive Cancer Center ( Site 1017)
RECRUITING

Iowa City, Iowa, 52242, United States
University of Texas MD Anderson Cancer Center ( Site 1007)
RECRUITING

Houston, Texas, 77030, United States
Universitätsklinikum Münster - Albert Schweitzer Campus-Pädiatrische Hämatologie und Onkologie ( Site 1141)
RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
Yale New Haven Hospital ( Site 1012)
RECRUITING

New Haven, Connecticut, 06510, United States

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