Centre Leon Berard

This Phase 3 trial tests whether a combination of two immunotherapy drugs (botensilimab and balstilimab) can help people with advanced stomach cancer live longer compared to standard treatment. The study includes 132 adults whose tumors have a specific genetic marker (MSI-H/dMMR)…

This study tests a program called PASCA that helps doctors detect and manage complications like high blood pressure, kidney failure, chronic pain, and fatigue in multiple myeloma patients after a stem cell transplant. About 204 adults aged 18 to 70 will be randomly assigned to ei…

This study tests two drugs—tarlatamab and temozolomide—in adolescents and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combination is safe and can shrink tumors. About 70 participants will be enrolled across multiple cente…

This phase 3 trial compares two strategies for people with high-risk cutaneous squamous cell carcinoma after surgery: adding radiation therapy versus simply monitoring. About 266 participants will be randomly assigned to one of the two groups and followed for at least two years. …

This study tests targeted cancer drugs in people with advanced solid tumors that have not responded to standard treatments. Participants receive a drug chosen based on the genetic changes in their tumor. The goal is to see if the treatment can stop or shrink the cancer for at lea…

This study tests two ideas at once: adding a drug called ATRA (Vesanoid) to standard treatment, and using a smaller radiation area that targets the tumor more precisely. It includes 460 adults with certain types of head and neck cancer that haven't spread across the midline. The …

This study tests whether adding the immunotherapy drug atezolizumab to the standard drug imatinib can help control advanced gastrointestinal stromal tumors (GIST) that have stopped responding to other treatments. About 110 adults with inoperable or metastatic GIST will be randoml…

This study tests whether the drug regorafenib can help prevent bone sarcomas from coming back after initial treatment. About 168 people aged 12 and older with various bone sarcomas will be randomly assigned to take regorafenib for up to 12 months or to receive standard monitoring…

This phase 2 trial tests whether the drug regorafenib can help keep high-grade bone sarcomas from growing in patients who still have some disease after standard treatment. About 36 people aged 12 and older will take regorafenib daily for up to 12 months. The main goal is to see h…

This study looks at whether women with a rare, slow-growing uterine cancer (low-grade endometrial stromal sarcoma) can safely stop taking their hormone-blocking pills (aromatase inhibitors) after long-term use. Half the participants will stop the pills and half will continue, and…

This study tests whether giving personalized diet and lifestyle advice to people who had a positive colorectal cancer screening (but no cancer) can help them adopt healthier habits and potentially prevent future cancer. 800 participants will be randomly assigned to receive the ad…

This study tests a new school-based program to encourage HPV vaccination among 11-17 year olds in France. HPV is a common virus that can cause cancer, but vaccination rates are low. The program will be used in middle and high schools, and researchers will check if more teens get …

This study tests a software tool called myDIET that helps manage nutrition in people with stomach or esophageal junction cancer who are scheduled for surgery. Patients answer simple questions about eating, weight, and symptoms, and the tool gives tailored advice. The goal is to s…

This study looks at whether a one-day hospital visit that includes medical, psychological, and social support can help teens and young adults (ages 15-25) feel better after finishing cancer treatment. About 214 participants who have completed treatment for a solid tumor or lympho…

This study tests whether a one-year supervised physical activity program can reduce long-term fatigue in men treated for metastatic testicular cancer. 236 participants will be randomly assigned to either the exercise program or standard recommendations. The main goal is to measur…

This study looks at whether it's possible to measure changes in taste, smell, and eating habits in children aged 7 to 17 who are undergoing cancer treatment. Researchers are testing simple tools like smell and taste tests, saliva measurements, and questionnaires. The goal is to s…

This study looks at how the drug venetoclax behaves in the bodies of 100 adults with acute myeloid leukemia (AML). Researchers will take extra blood samples to measure drug levels and see how they relate to treatment success. The study does not change the patient's regular care a…

This study looks at tumor samples from 300 people with exocrine pancreatic cancer to find links between genetic changes in the tumor and how the disease behaves. Researchers will use advanced DNA sequencing to analyze samples already collected from surgeries and biopsies. The goa…

This study is looking at how the immune system responds to breast and ovarian cancers. Researchers will analyze tumor and blood samples from 160 women before surgery to understand immune cell activity and find markers that might predict survival. The goal is to learn more about h…

This study looks at the immune cells and bacteria in colorectal tissue from people with benign or early-stage malignant growths. Researchers want to understand how the tissue environment changes as cancer develops. No treatments are tested; the goal is to gather information that …

This study looks at how a 13-week physical activity program influences motivation and psychological well-being in 80 women undergoing breast cancer treatment. Participants will complete questionnaires about their attitudes, confidence, and mood. The goal is to understand what hel…

This study looks at the genes of 750 people with advanced or metastatic pancreatic cancer. The goal is to find specific genetic changes that could help doctors choose better treatments, like targeted drugs or chemotherapy combinations. Participants must have a tumor sample availa…

This study compares two methods for marking non-palpable breast tumors before surgery: magnetic clips and traditional metal wires. Researchers will track costs, how well the marker finds the tumor, and patient satisfaction in 772 women across France. The goal is to see if magneti…