New combo therapy aims to fight Hard-to-Treat GIST tumors

NCT ID NCT05152472

Recruiting now Disease control Sponsor: Centre Leon Berard Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding the immunotherapy drug atezolizumab to the standard drug imatinib can help control advanced gastrointestinal stromal tumors (GIST) that have stopped responding to other treatments. About 110 adults with inoperable or metastatic GIST will be randomly assigned to receive either imatinib alone or imatinib plus atezolizumab. The main goal is to see if the combination slows disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: imatinib and atezolizumab
What this could lead to: If it works, this could offer a new treatment option for people with advanced GIST who have run out of standard therapies.
What could go wrong: This is an early phase 2 trial with only 110 participants, so results may not be conclusive. Adding atezolizumab may also increase side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastrointestinal stromal tumor neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED GASTROINTESTINAL STROMAL TUMOR (GIST) METASTATIC GASTROINTESTINAL STROMAL TUMOR UNRESECTABLE GASTROINTESTINAL STROMAL TUMOR (GIST)

Contacts and locations

Locations

CHU Poitiers
RECRUITING

Poitiers, 86000, France
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Eugène Marquis
RECRUITING

Rennes, 35042, France
Centre Léon Bérard
RECRUITING

Lyon, Rhône, 69373, France
Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Centre Paul Strauss
NOT_YET_RECRUITING

Strasbourg, 67033, France
Chru Tours
RECRUITING

Tours, 37044, France
Hôpital Robert Debré
RECRUITING

Reims, 51090, France
Hôpital de La Timone
RECRUITING

Marseille, 13385, France
ICANS CHRU de Strasbourg
TERMINATED

Strasbourg, 67200, France
Institut Bergonié
RECRUITING

Bordeaux, 33076, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Institut de cancérologie de l'Ouest
RECRUITING

Saint-Herblain, 44805, France

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