Supercharging the Body's own defenses to fight Hard-to-Treat GIST
NCT ID NCT07647068
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial tests whether a patient's own immune cells, called tumor-infiltrating lymphocytes (TILs), can be grown in a lab and then given back to fight advanced gastrointestinal stromal tumors (GIST). The study includes people whose GIST has spread, come back, or cannot be removed by surgery and has stopped responding to standard treatments. Participants receive chemotherapy to prepare their body, then the lab-grown TILs along with a drug called aldesleukin to boost the immune response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
autologous tumor infiltrating lymphocytes (TILs) plus aldesleukin
What this could lead to
If it works, this could offer a new treatment option for people with advanced GIST that has stopped responding to standard therapies.
What could go wrong
This is an early-phase trial with a small number of participants, so the treatment may not work for everyone. Side effects from chemotherapy and the immune response can be severe.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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