New drug targets rare sarcomas and GIST with genetic mutations

NCT ID NCT04595747

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests a drug called rogaratinib in about 48 people with advanced sarcoma or a rare type of GIST that has certain genetic changes. The drug works by blocking proteins that help cancer cells grow. The goal is to see if it can shrink tumors or slow the disease, while monitoring side effects.

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Conditions

The condition(s) this trial relates to.

gastrointestinal stromal tumor sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED GASTROINTESTINAL STROMAL TUMOR LOCALLY ADVANCED SARCOMA METASTATIC GASTROINTESTINAL STROMAL TUMOR METASTATIC SARCOMA STAGE III GASTRIC AND OMENTAL GASTROINTESTINAL STROMAL TUMOR AJCC V8 STAGE III SMALL INTESTINAL, ESOPHAGEAL, COLORECTAL, MESENTERIC, AND PERITONEAL GASTROINTESTINAL STROMAL TUMOR AJCC V8 STAGE IV GASTRIC AND OMENTAL GASTROINTESTINAL STROMAL TUMOR AJCC V8 STAGE IV SMALL INTESTINAL, ESOPHAGEAL, COLORECTAL, MESENTERIC, AND PERITONEAL GASTROINTESTINAL STROMAL TUMOR AJCC V8

Contacts and locations

Locations

City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
City of Hope at Irvine Lennar

Irvine, California, 92618, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
National Cancer Institute Developmental Therapeutics Clinic

Bethesda, Maryland, 20892, United States
National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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