Centre Leon Berard

This study is testing if adding a drug called atezolizumab (an immunotherapy) to the standard treatment of radiotherapy and surgery works better for soft tissue sarcoma. It will involve 62 adults with a type of sarcoma that can be removed by surgery. The main goal is to see if th…

This study is testing whether adding a medication called pegfilgrastim to standard pre-surgery treatment improves outcomes for people with HER2-positive breast cancer. Pegfilgrastim helps boost white blood cell counts. Researchers want to see if this boost helps the main cancer d…

This early-stage study is testing a focused ultrasound technique (HIFU) to destroy pancreatic tumors that cannot be removed by surgery. It is for patients whose cancer has not progressed after initial chemotherapy. The main goals are to see if the procedure is safe and if it help…

This study is testing whether giving an immunotherapy drug called pembrolizumab before surgery is safe and effective for patients with certain localized, operable cancers that have specific genetic features (MSI/dMMR). The main goal is to see if the treatment can completely elimi…

This study is testing if adding an experimental drug called NP137 to standard immunotherapy helps patients with advanced solid tumors. It focuses on people whose cancer has stopped responding well to their current immunotherapy. The goal is to see if the combination can better co…

This study is testing the safety and early effectiveness of a new two-drug combination (HDM201 and pazopanib) for adults with advanced soft tissue sarcoma that has a specific genetic profile (p53 wild-type). The first part finds the safest dose, and the second part looks for earl…

This study is testing a two-step treatment plan for adults newly diagnosed with a common type of chronic leukemia. First, patients take a stronger drug (ponatinib) for six months to deeply reduce the cancer. Then, they switch to a standard, gentler drug (imatinib) for up to three…

This study aims to see if automatically referring cancer patients to palliative care during emergency room visits leads to less aggressive medical treatments at the end of life and better quality of life. It will involve 240 adult cancer patients in France whose disease is not cu…

This study aims to understand and track the long-term health problems that can develop in cancer survivors after their initial treatment is successful. It follows 500 adults who have finished treatment for certain cancers (like breast cancer, lymphoma, and leukemia) and are in re…