Centre Leon Berard

This study tests a combination of two drugs—HDM201 and pazopanib—in people with advanced or metastatic soft tissue sarcoma that has a normal p53 gene. The trial has two parts: first, finding the safest dose of HDM201 when given with a fixed dose of pazopanib, and second, checking…

This study tests whether adding an experimental drug called NP137 to standard immunotherapy (PD-1/PD-L1 blockers) can help shrink or control advanced solid tumors that are stable or resistant to treatment alone. About 57 adults with various advanced cancers will receive the combi…

This study was designed to test the safety and effectiveness of two drugs, bemarituzumab and bevacizumab, given together to people with advanced gynecologic cancers (endometrial, ovarian, or cervical) that have a specific protein called FGFR2b. The trial was withdrawn before enro…

This trial tests a procedure called High-Intensity Focused Ultrasound (HIFU) for people with pancreatic cancer that cannot be removed by surgery. The study has two parts: first, checking how safe the procedure is, and second, seeing if it helps patients live longer. About 26 part…

This Phase 2 trial tests whether adding the immunotherapy drug atezolizumab to standard radiotherapy improves outcomes for people with soft tissue sarcoma. About 62 participants will receive treatment in different sequences: radiation before or after surgery, combined with atezol…

This study tests whether giving immunotherapy before surgery can help people with MSI/dMMR tumors. The goal is to shrink or eliminate the tumor before it is removed, potentially improving survival. The trial includes adults with localized, resectable cancers such as colorectal, g…

This study looks at whether adding pegfilgrastim (a drug that increases white blood cells) to standard chemotherapy and trastuzumab can help the immune system better attack HER2-positive breast cancer before surgery. About 90 women with early-stage, operable breast cancer will ta…

This phase 2 trial tests whether starting with a stronger drug (ponatinib) for 6 months, then switching to a standard drug (imatinib) for at least 30 months, can help adults with newly diagnosed chronic myeloid leukemia reach deep remission. The goal is to see if patients can the…

This study tests whether cancer patients who visit the emergency room for urgent problems benefit from being immediately referred to a palliative care team. The goal is to see if this reduces aggressive treatments and hospitalizations in the last month of life. The trial involves…

This study follows 500 adults aged 18-65 who completed chemotherapy for certain cancers and are in remission. Researchers will check for 19 possible late side effects over 5 years, including heart, lung, and hormone problems. The goal is to catch these issues early and connect pa…