New hope for kids with rare cancers: targeted drug shows promise

NCT ID NCT04616560

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 18 times

Summary

This study tests a drug called DS-8201a (trastuzumab deruxtecan) in children, teens, and young adults whose osteosarcoma, Wilms tumor, or desmoplastic small round cell tumor has come back or not responded to treatment. The drug works like a smart bomb, attaching to cancer cells and delivering chemotherapy directly to them. The goal is to find the safest dose and see if it can shrink tumors or slow the disease.

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Conditions

The condition(s) this trial relates to.

childhood kidney Wilms tumor desmoplastic small round cell tumor kidney Wilms tumor osteosarcoma Wilms tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DESMOPLASTIC SMALL ROUND CELL TUMOR OSTEOSARCOMA RECURRENT DESMOPLASTIC SMALL ROUND CELL TUMOR RECURRENT KIDNEY WILMS TUMOR RECURRENT OSTEOSARCOMA REFRACTORY DESMOPLASTIC SMALL ROUND CELL TUMOR REFRACTORY WILMS TUMOR WILMS TUMOR

Contacts and locations

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Locations

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
C S Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado
SUSPENDED

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital of Alabama
SUSPENDED

Birmingham, Alabama, 35233, United States
Children's Hospital of Orange County
SUSPENDED

Orange, California, 92868, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Children's Hospital of Pittsburgh of UPMC
SUSPENDED

Pittsburgh, Pennsylvania, 15224, United States
Children's Mercy Hospitals and Clinics
SUSPENDED

Kansas City, Missouri, 64108, United States
Children's National Medical Center
SUSPENDED

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center
SUSPENDED

Cincinnati, Ohio, 45229, United States
Dana-Farber Cancer Institute
SUSPENDED

Boston, Massachusetts, 02215, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Johns Hopkins All Children's Hospital
SUSPENDED

St. Petersburg, Florida, 33701, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Lucile Packard Children's Hospital Stanford University
RECRUITING

Palo Alto, California, 94304, United States
Lurie Children's Hospital-Chicago
SUSPENDED

Chicago, Illinois, 60611, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
SUSPENDED

New York, New York, 10032, United States
Primary Children's Hospital
SUSPENDED

Salt Lake City, Utah, 84113, United States
Riley Hospital for Children
SUSPENDED

Indianapolis, Indiana, 46202, United States
Saint Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States

Contact Email: •••••@•••••
UCSF Medical Center-Mission Bay
SUSPENDED

San Francisco, California, 94158, United States
UT Southwestern/Simmons Cancer Center-Dallas
SUSPENDED

Dallas, Texas, 75390, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Minnesota/Masonic Cancer Center
SUSPENDED

Minneapolis, Minnesota, 55455, United States
Vanderbilt University/Ingram Cancer Center
ACTIVE_NOT_RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••

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