Personalized cell therapy takes on childhood cancers

NCT ID NCT05642455

Recruiting now Disease control Sponsor: USWM CT, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times

Summary

This study tests a new treatment called afamitresgene autoleucel in children and young adults aged 2 to 21 with advanced cancers that have a specific marker (MAGE-A4). The treatment uses the patient's own immune cells, modified to attack the cancer. The main goals are to check safety and see if the tumors shrink.

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Conditions

The condition(s) this trial relates to.

malignant peripheral nerve sheath tumor neuroblastoma neurofibrosarcoma osteosarcoma synovial sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) NEUROBLASTOMA (NBL) OSTEOSARCOMA SYNOVIAL SARCOMA

Contacts and locations

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Locations

Children's Hospital of Philedephia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

Contact Email: •••••@•••••
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 10065, United States
Duke University School of Medicine
RECRUITING

Durham, North Carolina, 27710, United States
Memorial Sloan Kettering Kids
RECRUITING

New York, New York, 10065, United States
National Institutes of Health
RECRUITING

Bethesda, Maryland, 20892, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Stanford University
RECRUITING

Palo Alto, California, 94305, United States
University of Wisconsin Cancer Center
RECRUITING

Madison, Wisconsin, 53715, United States

Contact Email: •••••@•••••
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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