OSTEOSARCOMA

This study is testing a new drug called CLR 131 in children and young adults whose cancers have come back or haven't responded to standard treatments. The drug is designed to deliver radiation directly to cancer cells. The main goals are to find a safe dose and see if the drug sh…

This study is testing whether two immunotherapy drugs, nivolumab alone or combined with azacitidine, are safe and can help prevent cancer from coming back in patients with recurrent osteosarcoma (a type of bone cancer) that has spread to the lungs but can be surgically removed. P…

This study is testing a new combination of two drugs, cobolimab and dostarlimab, for children and young adults with advanced solid tumors that have not responded to other treatments. The main goals are to find the safest and most effective dose and to see how well the body tolera…

This early-stage study is testing a new combination treatment for children and young adults with advanced osteosarcoma or neuroblastoma that has come back or hasn't responded to standard therapies. Doctors take a patient's own immune cells, genetically modify them to better recog…

This study is testing if adding a daily pill called cabozantinib to standard supportive care helps control osteosarcoma (a type of bone cancer) for longer in children and young adults whose cancer cannot be fully removed by surgery. Participants, aged 5 to 30, will be randomly as…

This study is testing whether combining two drugs, olaparib and ceralasertib, can help control osteosarcoma (a type of bone cancer) that has come back or stopped responding to standard treatments. It is for patients aged 12 to 40. The main goal is to see if this combination can s…

This early-stage study is testing a new two-part treatment for osteosarcoma that has come back or not responded to standard therapies. Doctors take a patient's own immune cells (T cells), modify them in a lab to recognize a special marker, and then infuse them back. A second drug…

This study is testing whether combining two existing drugs, regorafenib and nivolumab, can better control advanced osteosarcoma (a type of bone cancer) that has come back or stopped responding to standard treatments. It will involve about 48 patients, including children and adult…

This small, early-stage study is testing whether a drug called glucarpidase can help adults with osteosarcoma (a type of bone cancer) better tolerate their chemotherapy. The goal is to see if giving glucarpidase after high-dose methotrexate treatment reduces side effects and lead…

This study is testing whether a pill called cabozantinib can help control rare cancers that have come back or stopped responding to other treatments in children and young adults. It includes patients with sarcomas, Wilms tumor, and other rare tumors. The drug aims to slow or stop…

This early-stage study is testing a new type of personalized cell therapy for children and young adults whose solid tumors have come back or haven't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cance…

This early-phase study is testing the safety and feasibility of a new treatment called CAR T-cell therapy for children and young adults whose solid tumors have come back or not responded to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to be…

This study is testing whether adding a drug called mifamurtide to standard chemotherapy after surgery helps patients with high-risk osteosarcoma (a type of bone cancer) live longer without their cancer returning. It will involve about 60 patients aged 2 to 50 who have already had…

This is an early safety study testing a new cancer vaccine called PeptiCRAd-1, given alongside the immunotherapy drug pembrolizumab. It aims to see if this combination is safe and can activate the immune system to fight cancer in patients with advanced solid tumors that have stop…

This study is testing a drug called trastuzumab deruxtecan (DS-8201a) for young people (ages 12-39) whose HER2-positive osteosarcoma, a type of bone cancer, has come back. The drug is designed to act like a targeted missile, attaching to cancer cells and delivering chemotherapy d…

This study is testing a new type of imaging scan to see if it can better detect and monitor tumors in children and young adults with cancer. The scan uses a radioactive form of a natural protein building block called methionine. Researchers want to see how well this new scan work…

This study aims to understand and track the long-term health problems that can develop in cancer survivors after their initial treatment is successful. It follows 500 adults who have finished treatment for certain cancers (like breast cancer, lymphoma, and leukemia) and are in re…

This study aims to understand why some bone cancers and solid tumors stop responding to chemotherapy drugs. Researchers will analyze tumor samples and blood from patients who have had surgery or biopsy to identify biological factors linked to treatment resistance. The goal is to …