New radioactive drug targets childhood cancers that Won't quit

NCT ID NCT03478462

Ongoing Disease control Sponsor: Cellectar Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a radioactive drug called CLR 131 in 30 children and young adults with solid tumors, lymphoma, or brain tumors that have come back or not responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. Participants receive the drug through an IV, and doctors monitor for side effects and any signs of cancer control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CLR 131 (a radioactive drug that targets cancer cells)
What this could lead to: If it works, this could point toward a new treatment option for children with cancers that have not responded to standard therapies.
What could go wrong: This is an early Phase 1 trial with only 30 participants, so it is too small to prove effectiveness. The drug is radioactive and may cause side effects like damage to healthy tissues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer childhood neoplasm desmoplastic small round cell tumor diffuse intrinsic pontine glioma ependymoma Ewing sarcoma glioblastoma glioma gliosarcoma Hodgkins lymphoma lymphoma medulloblastoma neuroblastoma Neuroectodermal Tumors, Primitive neuroepithelial neoplasm non-Hodgkin lymphoma osteosarcoma pediatric lymphoma rhabdoid tumor rhabdomyosarcoma sarcoma synovial sarcoma Wilms tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIPG EWING SARCOMA NEUROBLASTOMA OSTEOSARCOMA PEDIATRIC BRAIN TUMOR PEDIATRIC LYMPHOMA PEDIATRIC SOLID TUMOR RHABDOMYOSARCOMA

Contacts and locations

Locations

Children's Hospital at Westmead

Westmead, New South Wales, 2145, Australia
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Duke University

Chapel Hill, North Carolina, 27708, United States
Hospital for Sick Children

Toronto, Ontario, M5G1X8, Canada
Lucile Packard Children's Hospital

Palo Alto, California, 94304, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States

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