New drug combo shows promise for aggressive bone cancer

NCT ID NCT03643133

First seen Jan 04, 2026 · Last updated May 07, 2026 · Updated 23 times

Summary

This trial tests whether adding the drug mifamurtide to standard chemotherapy after surgery helps people with high-risk osteosarcoma (a type of bone cancer) live longer without the cancer coming back. The study includes 60 patients aged 2 to 50 with newly diagnosed, aggressive osteosarcoma that has spread or did not respond well to initial treatment. Participants are randomly assigned to receive either chemotherapy alone or chemotherapy plus mifamurtide.

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Contacts and locations

Locations

  • CHRU de Nancy - Onco-hématologie pédiatrique

    Vandœuvre-lès-Nancy, France

  • CHU Amiens-Picardie - Service d'oncologie hématologie pédiatrique

    Amiens, France

  • CHU Arnaud de Villeneuve - Onco-hématologie pédiatrique

    Montpellier, France

  • CHU Bretonneau - Service d'oncologie médicale

    Tours, France

  • CHU Toulouse - Hôpital des Enfants - Service d'Hémato-Immuno-Oncologie

    Toulouse, France

  • CHU d'Angers - Service d'oncologie pédiatrique

    Angers, France

  • CHU de Caen - Service d'oncologie hématologie pédiatrique

    Caen, France

  • CHU de Grenoble - Service d'oncologie hématologie pédiatrique

    La Tronche, France

  • CHU de Nantes - Service d'oncologie hématologie pédiatrique

    Nantes, France

  • CHU de Nice - Service d'oncologie hématologie pédiatrique

    Nice, France

  • Centre Eugène Marquis - Service d'oncologie médicale

    Rennes, France

  • Centre Léon Bérard - IHOPE

    Lyon, France

  • Centre Léon Bérard - Service d'oncologie médicale

    Lyon, France

  • Centre Oscar Lambret - Unité d'onco-pédiatrie

    Lille, France

  • Hôpital Armand Trousseau - Service d'hématologie et d'oncologie pédiatrique

    Paris, France

  • Hôpital Charles Nicolle - Hémato-Immuno-Oncologie Pédiatrique

    Rouen, France

  • Hôpital Clocheville - Hématologie et oncologie pédiatrique

    Tours, France

  • Hôpital Cochin

    Paris, France

  • Hôpital Hautepierre - Onco-hématologie pédiatrique

    Strasbourg, France

  • Hôpital de Hautepierre - Onco-hématologie adulte

    Strasbourg, France

  • Hôpital de la Timone - Service d'oncologie pédiatrique

    Marseille, France

  • Hôpital de la Timone - service d'oncologie médicale

    Marseille, France

  • Institut Bergonié - Service d'oncologie médicale

    Bordeaux, France

  • Institut Claudius Regaud - service d'oncologie médicale

    Toulouse, France

  • Institut Curie - Service d'oncologie médicale

    Paris, 75000, France

  • Institut Curie - Service d'oncologie pédiatrique

    Paris, France

  • Institut Gustave Roussy - Service d'oncologie médicale

    Villejuif, France

  • Institut Gustave Roussy - Service de cancérologie de l'enfant et de l'adolescent

    Villejuif, 94800, France

  • Institut de Cancérologie de Lorraine - Service d'oncologie médicale

    Vandœuvre-lès-Nancy, France

  • Institut de Cancérologie de l'Ouest (Site René Gauducheau) - Service d'oncologie médicale

    Saint-Herblain, France

  • Institut régional du Cancer de Montpellier - Service d'oncologie médicale

    Montpellier, France

Conditions

Explore the condition pages connected to this study.