Could a drug boost chemo for tough bone cancer?
NCT ID NCT03643133
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether adding mifamurtide to standard chemotherapy helps people with high-risk osteosarcoma, a type of bone cancer. The study includes 60 patients aged 2 to 50 with newly diagnosed, aggressive disease. Researchers will compare survival and relapse rates between those who get mifamurtide plus chemo and those who get chemo alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mifamurtide (MEPACT)
What this could lead to
If it works, this could point toward a more effective treatment for high-risk osteosarcoma, potentially improving survival rates.
What could go wrong
This is a small, early-phase trial with only 60 participants. The drug may not improve outcomes and could cause side effects like fever or fatigue.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHRU de Nancy - Onco-hématologie pédiatrique
Vandœuvre-lès-Nancy, France
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CHU Amiens-Picardie - Service d'oncologie hématologie pédiatrique
Amiens, France
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CHU Arnaud de Villeneuve - Onco-hématologie pédiatrique
Montpellier, France
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CHU Bretonneau - Service d'oncologie médicale
Tours, France
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CHU Toulouse - Hôpital des Enfants - Service d'Hémato-Immuno-Oncologie
Toulouse, France
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CHU d'Angers - Service d'oncologie pédiatrique
Angers, France
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CHU de Caen - Service d'oncologie hématologie pédiatrique
Caen, France
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CHU de Grenoble - Service d'oncologie hématologie pédiatrique
La Tronche, France
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CHU de Nantes - Service d'oncologie hématologie pédiatrique
Nantes, France
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CHU de Nice - Service d'oncologie hématologie pédiatrique
Nice, France
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Centre Eugène Marquis - Service d'oncologie médicale
Rennes, France
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Centre Léon Bérard - IHOPE
Lyon, France
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Centre Léon Bérard - Service d'oncologie médicale
Lyon, France
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Centre Oscar Lambret - Unité d'onco-pédiatrie
Lille, France
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Hôpital Armand Trousseau - Service d'hématologie et d'oncologie pédiatrique
Paris, France
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Hôpital Charles Nicolle - Hémato-Immuno-Oncologie Pédiatrique
Rouen, France
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Hôpital Clocheville - Hématologie et oncologie pédiatrique
Tours, France
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Hôpital Cochin
Paris, France
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Hôpital Hautepierre - Onco-hématologie pédiatrique
Strasbourg, France
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Hôpital de Hautepierre - Onco-hématologie adulte
Strasbourg, France
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Hôpital de la Timone - Service d'oncologie pédiatrique
Marseille, France
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Hôpital de la Timone - service d'oncologie médicale
Marseille, France
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Institut Bergonié - Service d'oncologie médicale
Bordeaux, France
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Institut Claudius Regaud - service d'oncologie médicale
Toulouse, France
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Institut Curie - Service d'oncologie médicale
Paris, 75000, France
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Institut Curie - Service d'oncologie pédiatrique
Paris, France
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Institut Gustave Roussy - Service d'oncologie médicale
Villejuif, France
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Institut Gustave Roussy - Service de cancérologie de l'enfant et de l'adolescent
Villejuif, 94800, France
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Institut de Cancérologie de Lorraine - Service d'oncologie médicale
Vandœuvre-lès-Nancy, France
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Institut de Cancérologie de l'Ouest (Site René Gauducheau) - Service d'oncologie médicale
Saint-Herblain, France
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Institut régional du Cancer de Montpellier - Service d'oncologie médicale
Montpellier, France