New combo therapy shows promise for tough bone cancer
NCT ID NCT04803877
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining two drugs, regorafenib and nivolumab, can help people with osteosarcoma (a type of bone cancer) that has returned or not responded to previous treatments. About 48 participants aged 5 and older will receive the combination. The main goal is to see if this approach improves the chance of living without the cancer growing for at least 4 months, compared to historical data with regorafenib alone.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital of Los Angeles
Los Angeles, California, 90027, United States
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Cincinnati Children's
Cincinnati, Ohio, 45229, United States
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Johns Hopkins
Baltimore, Maryland, 21287, United States
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Oregon Health and Sciences University
Portland, Oregon, 97239, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Miami
Miami, Florida, 33136, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States