Engineered immune cells plus chickenpox vaccine take on childhood cancers

NCT ID NCT01953900

First seen Jan 30, 2026 · Last updated Jun 19, 2026 · Updated 24 times

Summary

This early-phase study tests a new treatment for advanced osteosarcoma and neuroblastoma that has not responded to standard therapy. Researchers take a patient's own immune cells (T cells), add a gene to help them recognize and attack cancer cells, and combine them with a chickenpox vaccine to help the cells last longer in the body. The main goal is to find a safe dose and understand side effects in about 26 participants.

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Contacts and locations

Locations

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

Conditions

The condition(s) this trial relates to.

chickenpox neuroblastoma osteosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.