New combo attack on lung tumors: immunotherapy, radiation, and surgery

NCT ID NCT06492954

Recruiting now Disease control Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing whether combining an immunotherapy drug (atezolizumab) with targeted radiation and surgery is safe for people whose osteosarcoma has come back in the lungs. About 12 participants will receive the drug, radiation to one lung nodule, and then surgery to remove all visible lung tumors. The main goal is to find the safest dose and see if the combination can keep the cancer from growing for at least a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atezolizumab (an immunotherapy drug that helps the immune system attack cancer cells)
What this could lead to: If this combination proves safe and effective, it could offer a new treatment option for people whose osteosarcoma has come back in the lungs, potentially helping to control the disease longer.
What could go wrong: This is a very early Phase 1 trial with only 12 participants, so it is primarily testing safety and dosing. The combination may not work better than existing treatments, and side effects from immunotherapy, radiation, and surgery could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOSARCOMA PULMONARY RECURRENCE OF OSTEOSARCOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Chilldren's Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30322, United States

Contact Email: •••••@•••••

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