Engineered immune cells take on Hard-to-Treat sarcomas in first human test
NCT ID NCT07052383
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing a new cell therapy called DIT309 for people with advanced bone or soft tissue sarcomas that have stopped responding to standard treatments. The therapy uses the patient's own immune cells, modified to better recognize and attack cancer cells. The main goals are to check safety, find the highest safe dose, and see if the treatment can slow tumor growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DIT309 cell injection (CAR-T cells)
- What this could lead to
- If it works, this could point toward a new treatment option for advanced sarcomas that have not responded to standard therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 15 participants, so it is primarily testing safety and dosing. The therapy may not shrink tumors or could cause serious side effects like cytokine release syndrome.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shanghai General Hospital
RECRUITINGShanghai, Shanghai Municipality, China
Contact
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