Could extra chemo stop sarcoma from spreading?

NCT ID NCT04307277

Recruiting now Disease control Sponsor: Institut Claudius Regaud Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing whether adding four cycles of chemotherapy (doxorubicin-based) to standard surgery and radiation can improve outcomes for people with high-risk soft tissue sarcoma. The study will enroll 600 participants, with 250 high-risk patients randomly assigned to receive either standard care alone or standard care plus chemotherapy. The main goal is to see if the extra chemo helps prevent the cancer from spreading to other parts of the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Doxorubicin with Ifosfamide or Dacarbazine (chemotherapy)
What this could lead to: If it works, this could provide a new standard treatment option to delay or prevent cancer spread in high-risk soft tissue sarcoma patients.
What could go wrong: This is a Phase 3 trial, but results are not yet known. Chemotherapy has significant side effects, and the benefit may be small or not apply to all sarcoma types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOFT TISSUE SARCOMA

Contacts and locations

Locations

CHRU Besançon
RECRUITING

Besançon, France
CHU Limoges
RECRUITING

Limoges, France
CHU Marseille
RECRUITING

Marseille, France
CHU Poitiers
RECRUITING

Poitiers, France
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Eugène Marquis
RECRUITING

Rennes, 35042, France
Centre François Baclesse
RECRUITING

Caen, France
Centre Georges-François Leclerc
RECRUITING

Dijon, France
Centre Henri Becquerel
RECRUITING

Rouen, 76038, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, France
Centre Léon Bérard
RECRUITING

Lyon, France
Hôpital Cochin
RECRUITING

Paris, France
Hôpitaux Universitaires de Strasbourg
RECRUITING

Strasbourg, France
Institut Godinot
RECRUITING

Reims, France
Institut Paoli-Calmettes
RECRUITING

Marseille, 13273, France
Institut Universitaire du Cancer Toulouse Oncopole
RECRUITING

Toulouse, France
Institut de Cancérologie de Lorraine - Centre Alexis Vautrin
RECRUITING

Vandœuvre-lès-Nancy, France
Institut de Cancérologie de Montpellier
RECRUITING

Montpellier, France
Institut de Cancérologie de l'Ouest
RECRUITING

Saint-Herblain, France

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