Institut Claudius Regaud

This large study is testing if adding chemotherapy before and after surgery helps prevent the cancer from spreading in patients with a high-risk type of soft tissue sarcoma. It will compare standard surgery and radiation to that same treatment plus 12 weeks of chemotherapy. The g…

This study is testing whether a special pre-surgery rehabilitation program helps patients with limb sarcoma recover better after their operation. The program involves a team of health professionals who work with patients before surgery to improve their strength and function. Rese…

This study is testing if a shorter course of chemotherapy works as well as the standard longer course when combined with an immunotherapy drug for advanced head and neck cancer. It will involve 86 patients whose cancer has returned or spread and who have not yet received treatmen…

This international study is testing whether adding a specific lymph node surgery before standard chemoradiation treatment helps patients with advanced cervical cancer live longer without their cancer returning. The trial will compare two approaches: standard treatment alone versu…

This study is testing if adding precise, high-dose radiation to standard care helps people with advanced bladder cancer that has spread to other parts of the body live longer. It is for patients whose cancer has not gotten worse after initial chemotherapy and who have three or fe…

This study is testing a new type of targeted radiation therapy for children whose neuroblastoma has come back or hasn't responded to standard treatments. The main goal is to find the highest dose that is safe for children to receive. Up to 18 children will receive two treatments,…

This study is testing a new surgical method for rebuilding the mouth or throat after removing cancer. Surgeons will take a piece of skin and tissue from the groin area (external pudendal flap) to use in the reconstruction, hoping it causes fewer problems at the site where it's ta…

This study aims to understand why some glioblastoma brain tumors respond better than others to TTFields treatment. Researchers will collect blood samples and existing tumor tissue from 80 newly diagnosed patients to look for biological markers that predict treatment success. The …

This study aims to understand the lifetime risk of blood cancers for people who inherit a specific gene change called a DDX41 mutation. Researchers will follow families with this mutation to learn at what ages related cancers typically develop. The goal is to gather enough inform…

This study aims to discover why some ovarian cancers become resistant to standard platinum-based chemotherapy. Researchers will follow 600 patients for five years, collecting health data and biological samples during their normal treatment. The goal is to identify factors that ca…

This study aims to understand if a simple blood test can provide similar information about prostate cancer spread as PET scans. Researchers will collect blood samples from 80 prostate cancer patients before and during their standard treatment and compare these results with their …

This study aims to learn more about how the immune system interacts with rare types of soft tissue sarcoma. Researchers will observe 400 adult patients in France who have one of nine specific rare sarcoma subtypes. The goal is to collect detailed biological and clinical informati…

This study aims to find biological markers in the blood and tumors of patients receiving immunotherapy for advanced solid cancers. Researchers will collect samples from about 770 patients to learn why some people respond well to treatment while others experience side effects or s…

This study aims to understand why some people born with a specific gene change (GATA2 mutation) develop serious blood cancers like leukemia, while others do not. Researchers will follow 150 people with this mutation for up to five years, analyzing their stored blood and bone marr…

This study aims to find out if a simple blood test, called the Inflammation-Based Index (IBI), can predict how well patients with advanced intestinal neuroendocrine tumors will respond to a targeted radiation therapy called Lu-177 oxodotreotide. Researchers will follow 150 patien…

This study aims to understand how radiation treatment for brain tumors affects memory and thinking skills in children years later. Researchers will follow 130 children in France, aged 4-12 at the time of their radiation, testing their memory and brain function two and four years …

This study aims to create a detailed atlas of proteins and cell structures within different types of breast cancer. Researchers will analyze tumor samples from 1,050 patients with early-stage or newly diagnosed metastatic breast cancer. The goal is to understand how fat storage a…

This study aims to understand how different cancers interact with the body's immune system, particularly focusing on immune cells called T cells. Researchers will collect tissue and blood samples from 1,100 patients with seven types of solid tumors over five years. The goal is to…

This study aims to understand why some advanced breast cancers with BRCA gene mutations stop responding to a specific class of drugs called PARP inhibitors. Researchers will collect tumor and blood samples from 120 patients to look for specific biological markers linked to drug r…

This study aims to understand if a patient's body weight affects how much of the breast cancer drug Trastuzumab-Deruxtecan stays in their blood and what side effects they experience. It will enroll 210 people with advanced breast cancer, comparing those with normal weight to thos…

This study is testing whether a blood test can detect early signs that a specific ovarian cancer treatment is becoming less effective. Researchers will collect blood samples from 130 patients with BRCA-mutated ovarian cancer who are receiving standard maintenance therapy. The goa…