Institut Claudius Regaud

This study tests whether adding 4 cycles of chemotherapy around the time of surgery can help prevent the spread of a rare, high-risk soft tissue sarcoma. About 600 adults with resectable tumors will be screened; those with a high-risk genetic signature will be randomly assigned t…

This study is for people with a type of head and neck cancer that has come back or spread. It tests whether giving only 4 cycles of chemotherapy (instead of the usual 6) together with the immunotherapy drug pembrolizumab can still control the cancer while causing fewer side effec…

This study tests whether adding focused radiation to standard treatment helps people with metastatic bladder cancer live longer. It includes patients whose cancer has not worsened after initial therapy and who have three or fewer remaining tumors. About 130 participants will be r…

This study looks at whether surgically removing lymph nodes near the aorta before standard chemoradiation helps people with stage IIIC1 cervical cancer live longer without the disease coming back. About 510 participants will be randomly assigned to either standard treatment or st…

This study tests whether a personalized pre-surgery program of physical therapy, exercise, and nutrition can help people with bone or soft-tissue sarcoma of the arm or leg recover better after surgery. About 53 participants will follow the program before their operation and be mo…

This study looks at whether medical hypnosis can help reduce anxiety in cancer patients who are moderately to very anxious during their radiation treatments. About 45 adults with solid tumors will be randomly assigned to either listen to music or listen to music plus receive hypn…

This study looks at whether a score based on two common blood markers (CRP and albumin) can predict if a patient's tumor will shrink or stop growing after Lu-177 treatment. About 150 adults with advanced intestinal neuroendocrine tumors will be followed for 3 years. The goal is t…

This study looks at people with a GATA2 gene mutation to find clues that might predict if they will develop serious blood cancers like leukemia or myelodysplastic syndromes. Researchers will collect blood and bone marrow samples over 5 years from 150 participants and review medic…

This study is looking at whether a blood test that finds prostate cancer cells can give similar information as a special PET scan. About 80 men with prostate cancer will give a blood sample before their PET scan. Researchers will compare the results to see if the blood test can h…

This study aims to understand why some ovarian cancers become resistant to platinum-based chemotherapy. Researchers will follow 600 patients for 5 years, collecting medical data and biological samples (blood, tumor, and fluid samples) during standard care. No extra procedures are…

This study aims to find biological markers in blood and tumor samples that can predict how well immunotherapy works and what side effects may occur. It will enroll 770 adults with advanced solid cancers like lung, head and neck, melanoma, or bladder cancer who are receiving immun…

This study is testing a new surgical technique to rebuild parts of the mouth or throat after cancer removal. The new method uses a skin flap from the groin area (external pudendal flap) instead of the usual donor sites, hoping to cause fewer complications. The study will include …

This study is collecting blood and tumor samples from 1100 people with various cancers (like head and neck, ovarian, and lung cancer) to learn how immune cells called T cells behave. The goal is to understand why some cancers are better at hiding from the immune system. Participa…

This study explores whether using alternative or complementary therapies (like herbal supplements) influences how well patients with early-stage breast cancer stick to their tamoxifen treatment. Researchers will follow 200 patients for one day to measure adherence and check tamox…

This study looks at whether being overweight or obese changes how much of the drug Trastuzumab-Deruxtecan (T-DXd) stays in the body and how it affects side effects in people with advanced breast cancer. Researchers will compare drug levels and side effects between normal-weight a…

This study will collect blood and tumor samples from 80 people with newly diagnosed glioblastoma to look for biological markers that predict how the tumor responds to TTFields (electric field therapy). Participants will receive standard treatment plus TTFields, and samples will b…

This study is collecting tissue samples from 1,050 people with early or metastatic breast cancer to create a detailed map of fat storage and protein patterns inside cancer cells. The goal is to better understand how different breast cancer subtypes behave. Participants provide sa…

This study follows 130 children who had radiation for a brain tumor between ages 4 and 12. Researchers will test their memory and attention 2 and 4 years after treatment, and also look at brain scans to see how radiation doses to the hippocampus relate to memory problems. The goa…

This study is for people with a DDX41 gene mutation that may increase the risk of blood diseases like leukemia. Researchers will follow up to 910 participants, including patients and their family members, to see how many develop blood problems over time. The goal is to create bet…

This study aims to understand why some breast cancers with BRCA mutations become resistant to PARP inhibitor drugs. Researchers will analyze tumor and blood samples from 120 patients with advanced breast cancer to see if certain proteins (POLQ, Shieldin complex, 53BP1) can predic…

This study aims to learn more about the immune system's role in rare soft tissue sarcomas. Researchers will collect and analyze blood and tumor samples from 400 patients with these uncommon cancers. The goal is to find patterns that could help predict how the disease will progres…