Institut Claudius Regaud

This study tests a shorter, higher-dose radiation therapy given over one week before surgery for soft tissue sarcoma in patients aged 70+ or those 65+ who are considered fragile. The goal is to see if this approach reduces major wound complications after surgery. About 48 partici…

This study looks at whether surgically removing para-aortic lymph nodes before standard chemoradiation can improve disease-free survival in people with stage IIIC1 cervical cancer. About 510 participants will be randomly assigned to either standard treatment or surgery plus tailo…

This Phase 3 trial is testing whether adding four cycles of chemotherapy (doxorubicin-based) to standard surgery and radiation can improve outcomes for people with high-risk soft tissue sarcoma. The study will enroll 600 participants, with 250 high-risk patients randomly assigned…

This phase 2 trial is testing whether giving only 4 cycles of chemotherapy alongside the immunotherapy drug pembrolizumab can effectively treat PD-L1-positive head and neck cancer that has spread or come back. Standard treatment usually involves 6 cycles of chemo. The study will …

This study tests whether adding focused radiation to standard treatment helps people with metastatic bladder cancer live longer. It includes patients whose cancer has not worsened after initial therapy and who have three or fewer remaining tumors. About 130 participants will be r…

This study tests a new surgical technique using a thin skin flap from the groin area to rebuild the mouth or throat after cancer removal. The goal is to see if it causes fewer problems at the donor site compared to standard flaps. Forty adults with head and neck cancer will be fo…

This study is testing a new way to manage care for 33 cancer patients who take oral chemotherapy at home. Instead of going to the hospital every month just to pick up medicine, a nurse will visit them at home twice in six months. An advanced practice nurse will coordinate everyth…

This study tests whether a series of sexology consultations can help people who had their voice box removed due to throat cancer, along with their partners, feel better about their intimate lives. The program involves individual talks with a trained sexology nurse and questionnai…

This study looks at whether medical hypnosis can help reduce anxiety in people with solid tumors who are getting radiation therapy. About 45 moderately to very anxious patients will either listen to relaxing music alone or combine it with hypnosis during their sessions. The goal …

This study tests whether a personalized program of exercise, nutrition advice, and mental support before surgery can improve recovery and quality of life in people with bone or soft-tissue sarcoma of the arm or leg. About 53 participants will be followed for two years after surge…

This study enrolls 68 healthy volunteers (cancer-free adults working at a French hospital) to help validate new blood-based DNA analysis methods. Participants give one blood sample, which is tested for cancer-related genetic mutations using advanced sequencing and PCR techniques.…

This study tracks 770 adults with advanced solid cancers (like lung, head and neck, melanoma, or bladder cancer) who are receiving immunotherapy. Researchers collect tumor and blood samples over time to find biological markers that predict how well the treatment works or causes s…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study looks back at data from 370 children treated for ependymoma, a common brain tumor in kids. Even after surgery and radiation, about half of these tumors return. Researchers are using artificial intelligence to analyze medical images, genetics, and treatment records to f…

This study compares three different blood tests (CellSearch, Parsortix, and SmartCatch) to see which one best detects circulating tumor cells in patients with metastatic breast or prostate cancer. Researchers will take blood samples from 54 patients before they start a new treatm…

This study is investigating whether a patient's body weight changes how the drug Trastuzumab-Deruxtecan (T-DXd) behaves in the body. Researchers will compare drug levels and side effects between normal-weight and overweight or obese patients with advanced breast cancer. The goal …

This study explores whether using alternative and complementary therapies, like turmeric supplements, affects how well early-stage breast cancer patients stick to their tamoxifen treatment. Researchers will follow 200 patients for one day to measure medication adherence and tamox…

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …

This study is collecting tumor and blood samples from 120 people with advanced, HER2-negative breast cancer who have a BRCA1/2 mutation. Researchers want to see if certain DNA repair proteins (POLQ, Shieldin complex, 53BP1) can predict whether a tumor will resist PARP inhibitor d…

This study will collect blood and tumor samples from 80 people with newly diagnosed glioblastoma to find biological markers that show whether a treatment called TTFields (tumor-treating fields) is working. The goal is to understand why some patients respond and others don't. Part…

This study is collecting tumor samples from 1,050 people with early or metastatic breast cancer to analyze fat storage and organelle properties in cancer cells. Researchers aim to create a detailed atlas of these features across different breast cancer subtypes. The goal is to be…

This study is collecting tumor and blood samples from 400 people with rare soft tissue sarcomas to learn how their immune system reacts to the cancer. Researchers will also track patients' health over time to see how the disease progresses. The goal is to find clues that could le…

This study follows 150 people with a GATA2 gene mutation to learn what factors predict if they will develop serious blood cancers like MDS or AML. Researchers will collect blood and bone marrow samples over 5 years and also review past data from 100 other patients. The goal is to…

This study looks at families who carry a change in the DDX41 gene, which may raise the risk of blood cancers like leukemia. Researchers will collect health questionnaires and saliva samples from up to 910 people to track who develops blood problems and when. The goal is to better…

This study looks at whether a blood test can find genetic changes in tumor DNA that signal ovarian cancer is coming back. It involves 130 women with BRCA mutations who are taking a maintenance drug called Olaparib after initial treatment. The goal is to see if these blood tests c…

This study looks at whether an inflammation-based score (using CRP and albumin levels) can predict how well patients with advanced intestinal neuroendocrine tumors respond to Lu-177 oxodotreotide therapy. Researchers will follow 150 patients for 36 months, collecting blood sample…

This study is looking at why some ovarian cancers become resistant to platinum-based chemotherapy, a common treatment. Researchers will collect blood, tumor, and fluid samples from 600 patients over five years, alongside their medical data. No new drugs are being tested—the goal …

This study is testing whether a blood test can detect prostate cancer cells that have spread, similar to a special PET scan. Researchers will take blood samples from 80 prostate cancer patients before their PET scans and compare the results. If the blood test works well, it might…

This study will collect blood and tumor samples from 1,100 people with various cancers, including head and neck, ovarian, cervical, lung, and brain cancers. Researchers want to learn how immune cells called T cells behave in these tumors. The goal is to better understand why some…