Institut Claudius Regaud

This study tested a surgery called nipple-sparing mastectomy in 450 women with early-stage breast cancer. The goal was to see if removing the breast tissue while keeping the nipple and skin could keep cancer from coming back in that area. The approach aims to improve how the brea…

This study tested a drug called sunitinib in 21 people with kidney cancer that had spread to the brain. The goal was to see if the drug could shrink brain tumors. Sunitinib works by blocking enzymes that help cancer cells grow and by cutting off blood flow to tumors. The study wa…

This study tested a new approach for people whose glioblastoma (a type of brain cancer) has come back after initial treatment. It combined focused radiation therapy with an immunotherapy drug called durvalumab, which helps the immune system fight cancer. The goal was to see if th…

This early-stage study tested a type of radiation therapy called PRRT in one child with neuroblastoma that had come back or not responded to standard treatments. The therapy uses a radioactive drug that targets tumor cells. The main goal was to find the safest dose and monitor si…

This study tested a two-step high-dose chemotherapy plan for 101 people with germ cell tumors that returned or didn't respond to initial treatment. The approach used paclitaxel and ifosfamide first, then carboplatin and etoposide, with carboplatin doses tailored to each patient t…

This study looked at whether measuring drug levels in the blood and adjusting doses accordingly can improve treatment for advanced kidney cancer. 47 patients taking sunitinib or pazopanib were followed to see if this approach reduced side effects and delayed cancer progression. T…

This early-phase trial tested a drug called cilengitide given continuously alongside standard chemotherapy and radiation in 14 people with advanced non-small cell lung cancer that could not be removed by surgery. The main goal was to find the highest safe dose of cilengitide when…

This study tested a new way to treat low-risk prostate cancer by placing tiny radioactive seeds only in the tumor area, not the whole prostate. 18 men with early-stage cancer received this focal therapy. The main goal was to see if the radiation dose could be delivered accurately…

This early-phase study tested whether adding a TNF-blocking drug (infliximab or certolizumab) to standard immunotherapy (nivolumab and ipilimumab) is safe for people with advanced melanoma. 33 adults with metastatic or unresectable melanoma participated. The main goal was to find…

This study looked at how well two different PET-CT scanners can find very small cancer spots (less than 1 cm) in 24 cancer patients. Patients were grouped by body size (BMI). Each person had two scans, one on each machine. The goal was to see which scanner finds more tiny lesions…

This study tested a special PET scan tracer (F-DOPA) to see if it could better detect leftover medullary thyroid cancer in 24 adults who had high tumor marker levels after surgery. The goal was to compare this new imaging method with standard scans to find remaining cancer in lym…

This study tested a capsaicin patch (Qutenza) against a standard nerve pain pill (amitriptyline) in 13 people who had head and neck cancer and still had nerve pain after treatment. The goal was to see if the patch could lower pain by at least 2 points on a 0-10 scale over 9 month…

This study looked at whether the body's natural 24-hour cycle (circadian rhythm) influences the spread of tumor cells in the blood of people with advanced lung cancer. Researchers collected blood samples from 27 patients before they started cancer treatment. The goal was to bette…

This study aims to create and test a scoring system that helps doctors identify which patients with metastatic breast cancer are likely to live longer with a third round of chemotherapy. Researchers will collect information from 267 women, including standard tests and a newer tes…

This study looked at whether it is possible to measure certain cholesterol-related substances, called oxysterols, in the blood of women with breast cancer who are taking hormone therapy like tamoxifen or aromatase inhibitors. The goal was to see if these measurements could help u…

This study looked at how the anti-nausea medication aprepitant changes the amount of the chemotherapy drug ifosfamide in the blood of people with soft tissue sarcoma. 59 patients receiving doxorubicin and ifosfamide were followed for two treatment cycles. Blood samples were taken…

This study looked at whether a special organized consultation when leaving the hospital helps people with metastatic cancer. 667 patients were split into two groups: one got the usual discharge instructions, and the other had a meeting with their doctor and a specialist to plan t…

This study looked at whether following national guidelines for ovarian cancer surgery is cost-effective. Researchers measured the cost per year of good-quality life (QALY) for 200 women with advanced ovarian cancer. The goal was to see if sticking to guidelines provides better va…

This study tested whether a special MRI technique can identify areas inside glioblastoma brain tumors that are rich in cancer stem cells. Researchers collected tissue samples from 21 patients during surgery and compared imaging data with lab tests. The goal was to learn more abou…

This study involved 60 people with advanced melanoma who were already scheduled to receive immunotherapy drugs (either a single drug or a combination). Researchers collected blood samples before and during treatment, and tumor samples when possible, to look for markers that might…

This study enrolled 2000 women with hormone-sensitive breast cancer who were already scheduled to receive hormone therapy after surgery. Researchers measured drug levels in the blood and analyzed genetic differences to see how these factors relate to side effects and early cancer…

This study looked at 60 people with metastatic breast cancer to find out if certain cells in their blood come from the tumor. Researchers took a blood sample before starting treatment and checked for these cells. The goal was to better understand the disease, not to test a new tr…

This study looked at whether tiny molecules called microRNAs in the blood can help doctors know if hormone therapy will work for women with advanced breast cancer. Researchers tested blood samples from 39 women before and after one month of treatment with tamoxifen or an aromatas…

This study looked at 60 people with a type of blood cancer called diffuse large B-cell lymphoma. Researchers used advanced techniques to create a detailed map of the cancer cells and immune cells in the body. The goal was to find markers that could help track how the disease chan…

This study followed 150 adults with solid tumors who were starting immunotherapy. Researchers collected data on side effects and quality of life during routine treatment. The goal was to better understand how and when side effects occur, helping doctors manage them more effective…