Institut Claudius Regaud

This study tested whether adding the drug ZARNESTRA to standard radiation therapy can slow tumor growth in people with glioblastoma, an aggressive brain cancer. Twenty-seven patients took the drug daily starting a week before radiation and continuing through treatment. The main g…

This phase 2 study looked at women with invasive breast cancer who had a mastectomy with immediate prosthetic breast reconstruction, followed by TomoTherapy (a type of radiation) with or without chemotherapy. The goal was to see how often the reconstruction was successful. 66 pat…

This study tested whether a combination of two chemotherapy drugs, gemcitabine and cisplatin, can shrink tumors in people with advanced or metastatic penile cancer. Fifty adults with inoperable or spreading disease took part. The main goal was to see how many patients responded t…

This early-stage trial tested a radioactive drug called 177Lu-DOTATATE in one child with neuroblastoma that had come back or not responded to standard treatments. The drug targets tumor cells that have a specific marker (somatostatin receptors). The goal was to find a safe dose. …

This phase 2 trial tested a high-dose chemotherapy regimen called TICE in 101 patients with germ cell tumors that had relapsed or were not responding to standard treatment. The approach uses two cycles of paclitaxel and ifosfamide followed by three cycles of carboplatin and etopo…

This study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…

This phase 2 trial tested the drug sunitinib in 21 patients with kidney cancer that had spread to the brain. The goal was to see if the drug could shrink brain tumors by blocking blood flow and cell growth. Researchers measured how many patients had a response after two treatment…

This study tested a precise radiation implant (brachytherapy) for men with low-risk prostate cancer. Instead of treating the whole prostate, doctors placed radioactive seeds only in the tumor area. The goal was to see if this targeted approach could deliver the right radiation do…

This early-phase trial tested the drug cilengitide given continuously along with standard chemotherapy and radiation in 14 patients with locally advanced non-small cell lung cancer. The main goal was to find the highest safe dose of cilengitide when used this way. Researchers als…

This study tested whether adding the immunotherapy drug durvalumab to targeted radiation can help people with recurrent glioblastoma, an aggressive brain cancer that has come back after initial treatment. The trial enrolled 108 adults and first checked safety, then randomly assig…

This early-phase study tested whether adding a TNF-blocking drug (infliximab or certolizumab) to standard immunotherapy (nivolumab and ipilimumab) is safe for people with advanced melanoma that has spread. The main goal was to find the best dose and check for serious side effects…

This study tested whether measuring drug levels in the blood can help doctors adjust doses of two common kidney cancer medications, sunitinib and pazopanib. The goal was to see if this personalized approach reduces side effects and keeps the cancer from growing longer than the st…

This study tested whether a special PET scan tracer called 18F-DOPA can better detect leftover medullary thyroid cancer in lymph nodes after surgery, compared to standard imaging. Twenty-four adults with elevated thyrocalcitonin levels (a sign of residual disease) received the tr…

This study compared a capsaicin patch (Qutenza) to a standard nerve pain medication (amitriptyline) in 13 head and neck cancer survivors with long-term nerve pain. The goal was to see if the patch could reduce pain and improve quality of life. Participants received either the pat…

This study collects standard-of-care images from people with differentiated thyroid cancer who are treated with radioactive iodine (Iodine-131). The goal is to better understand how much radiation reaches healthy organs and what dose is needed to destroy thyroid tissue. By gather…

This study looks at whether it's possible for people diagnosed with solid tumors to have a follow-up visit with their general practitioner within 15 days of learning their diagnosis. Researchers will track how many patients actually attend this visit and why some might not. The g…

This study collected information from 93 men who have had breast cancer. Participants filled out a questionnaire about their life, work, family, and health history. The goal is to find patterns that might help explain why some men develop breast cancer. No treatments or drugs wer…

This study aims to develop and validate a scoring system to identify which patients with metastatic breast cancer are likely to live longer with third-line chemotherapy. Researchers will collect clinical, histological, and biological data from 267 women starting a third line of t…

This study tested two different PET-CT scanners to see which one is better at finding very small cancer spots (less than 1 cm) in patients. Twenty-four people with cancer each had two scans, one on each machine. The researchers then added virtual lesions to the images to compare …

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

This study tested whether a planned meeting between a hospitalized cancer patient, their family doctor, and a specialist could reduce unplanned hospital visits. 667 adults with metastatic solid tumors were randomly assigned to either the standard discharge process or this organiz…

This study looked at how a person's genes and drug levels in the blood affect hormone therapy for breast cancer. It included 2000 women with hormone-sensitive breast cancer who were already scheduled for adjuvant hormone therapy. Researchers measured drug levels and genetic marke…

This study looked at whether following national guidelines for ovarian cancer surgery is cost-effective. Researchers measured the cost per quality-adjusted life year (QALY) over three years in 200 women with advanced ovarian cancer. The goal was to understand the economic impact …

This study looked at 59 people with soft tissue sarcoma who were getting chemotherapy with doxorubicin and ifosfamide. Researchers wanted to see if adding the anti-nausea drug aprepitant changed the amount of ifosfamide in the blood. Patients had blood samples taken during their …

This study looked at whether it's possible to measure certain substances called oxysterols in the blood of breast cancer patients. 29 women taking hormonal therapy (tamoxifen or anti-aromatase drugs) had their blood tested before and 28 days after starting treatment. The goal was…

This study involved 60 people with advanced melanoma who were already scheduled to receive immunotherapy drugs. Researchers collected blood samples and, when possible, tumor samples before and during treatment to look for biological markers that might predict whether the treatmen…

This study looked at whether a special MRI technique can identify the most aggressive parts of a glioblastoma brain tumor. Researchers took tissue samples from different areas of the tumor during surgery and tested them for cancer stem cells. The goal was to see if MRI markers ma…

This study looked at whether tiny molecules called microRNAs in the blood can help predict if hormone therapy will work for women with advanced breast cancer. Researchers tested blood samples from 39 women before and after one month of treatment with tamoxifen or an aromatase inh…

This study looked at whether the time of day affects the number of cancer cells in the blood of people with advanced lung cancer. Researchers took blood samples from 27 patients at 4 a.m. and 10 a.m. before starting treatment. The goal was to see if circadian rhythms influence ho…

This study looked at 60 people with diffuse large B-cell lymphoma who were starting standard chemotherapy (R-CHOP). Researchers used advanced single-cell technology to analyze tumor and blood samples over two years. The goal was to find biomarkers that could help predict how well…

This study looked at 60 people with metastatic breast cancer to find out whether certain cells in their blood (called DP-circulating cells) come from the tumor. Researchers took a blood sample before starting treatment and checked tumor samples. The goal was to better understand …