New combo approach for breast cancer: reconstruction and radiation together

NCT ID NCT03627988

Completed Disease control Sponsor: Institut Claudius Regaud Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study looked at women with invasive breast cancer who had a mastectomy with immediate prosthetic breast reconstruction, followed by TomoTherapy (a type of radiation) with or without chemotherapy. The goal was to see how often the reconstruction was successful. 66 patients were followed for up to 3 years. The study measured success rates, treatment quality, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mastectomy with immediate prosthetic breast reconstruction and TomoTherapy radiation
What this could lead to: If successful, this approach could offer a safe and effective way to combine breast reconstruction with radiation therapy after mastectomy, improving cosmetic outcomes without delaying cancer treatment.
What could go wrong: This is a small, non-randomized phase 2 study with only 66 participants, so results may not apply to everyone. Complications from surgery or radiation, such as infection or implant issues, are possible.

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Conditions

The condition(s) this trial relates to.

invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER INVASIVE

Contacts and locations

Locations

Institut Bergonie

Bordeaux, France
Institut Universitaire Du Cancer de Toulouse - Oncopole

Toulouse, 31059, France

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