SOFT TISSUE SARCOMA

This early-phase study is testing the safety of combining a new cancer vaccine with an existing immunotherapy drug (pembrolizumab) in patients with advanced solid tumors that have spread and stopped responding to standard treatments. The vaccine is designed to train the immune sy…

This study is testing whether injecting a modified virus (talimogene laherparepvec) directly into a tumor, along with standard radiation therapy, is safe and effective for patients with advanced soft tissue sarcoma before they have surgery. The goal is to see if this combination …

This study is testing a more precise form of radiation therapy for children and young adults with bone and soft tissue cancers like sarcoma. The goal is to see if using advanced imaging to guide the radiation can better control the tumor while causing fewer long-term side effects…

This study is testing whether combining two existing cancer drugs can help control advanced cancers that usually don't respond to standard immunotherapy. The trial is for adults with specific advanced cancers, like certain types of pancreatic, breast, and prostate cancer, who hav…

This study is testing a two-part treatment for soft tissue sarcoma that can be removed by surgery. First, doctors inject a modified cold sore virus (T-VEC) directly into the tumor to help the immune system attack the cancer. Then, patients receive a standard course of radiation t…

This early-stage trial is testing the safety of a new combination treatment for people with advanced cancers that have spread and cannot be removed by surgery. Doctors inject immune-stimulating drugs directly into a tumor, then give a small dose of radiation to that same spot. Th…

This study is testing a pill called LOXO-292 in children and teenagers with advanced solid or brain tumors that have a specific genetic change called a RET alteration. The goal is to find a safe and effective dose and to see if the medicine can shrink these difficult-to-treat tum…

This large study is testing whether analyzing a patient's tumor genetics can lead to more effective, personalized treatment for advanced soft-tissue sarcoma. About 600 patients will be randomly assigned to either receive treatment based on their genetic test results or receive st…

This study is testing a personalized cell therapy called LN-145 for patients with advanced cancers that have stopped responding to standard treatments. Doctors collect a patient's own immune cells from their tumor, grow large numbers of them in a lab, and then infuse them back in…

This early-stage trial is testing a new three-part treatment for people with intermediate or high-grade soft tissue sarcoma in the arms, legs, or trunk. Before surgery, participants receive a new drug called ADI-PEG 20 along with a standard chemotherapy (ifosfamide) and radiation…

This study is testing whether a pill called cabozantinib can help control rare cancers that have come back or stopped responding to other treatments in children and young adults. It includes patients with sarcomas, Wilms tumor, and other rare tumors. The drug aims to slow or stop…

This early-stage study is testing a new type of personalized cell therapy for children and young adults whose solid tumors have come back or haven't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cance…

This study is testing whether a combination of two immunotherapy drugs, etrumadenant and zimberelimab, can help control advanced dedifferentiated liposarcoma. It is for adults whose cancer has spread, returned after prior treatment, or cannot be removed by surgery. The main goal …

This study is testing a much shorter, 5-day radiation schedule given before surgery for soft tissue sarcoma in the arms or legs. The goal is to see if this approach is practical for patients and doctors, and if it works as well as the standard 5-6 week schedule. Researchers will …

This early-phase study is testing the safety and feasibility of a new treatment called CAR T-cell therapy for children and young adults whose solid tumors have come back or not responded to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to be…

This study is testing a two-part treatment for people with locally advanced soft tissue sarcomas, a type of cancer. Before surgery, patients receive a modified virus injected directly into the tumor along with standard radiation therapy. The goal is to see if this combination can…

This study is testing whether using a lower dose of radiation and targeting a smaller area after sarcoma surgery is as effective as the standard, higher-dose treatment. Researchers want to see if this approach still controls the cancer while causing fewer and less severe long-ter…

This study aims to find the best way to prevent dangerous blood clots in patients having surgery for bone or soft tissue cancer in the leg or pelvis. It will compare two common prevention methods: daily aspirin pills versus daily blood-thinner injections (LMWH). Researchers want …

This study is testing a personalized computer tool called PERSARC. It helps patients with aggressive soft-tissue sarcoma in their arms or legs understand the risks and benefits of their treatment options. The goal is to see if using this tool helps patients feel more confident an…