SOFT TISSUE SARCOMA

This study tested whether patients with advanced soft tissue sarcoma whose cancer was controlled after six cycles of chemotherapy should continue treatment or take a planned break. Fifty-three patients whose cancer had not progressed were randomly assigned to either keep receivin…

This study tested whether combining two chemotherapy drugs, nab-paclitaxel and gemcitabine, could help control cancer in teenagers and young adults whose bone or soft tissue sarcoma had returned or stopped responding to standard treatments. The main goals were to see if the combi…

This early-stage study tested whether combining two drugs—trabectedin and durvalumab—is safe and shows promise for treating advanced soft-tissue sarcoma and ovarian cancer. The trial involved 40 patients whose cancers had progressed despite previous treatments. Researchers aimed …

This study tested a two-step immunotherapy for people with advanced soft tissue sarcoma that had stopped responding to standard treatments. First, a drug called LTX-315 was injected into one tumor to help attract the patient's own immune cells. Then, those immune cells were colle…

This study tested whether adding a drug called Fluzoparib to a specific type of radiation treatment before surgery could help people with soft tissue sarcoma in their arms, legs, or torso. The goal was to see if this combination was safe, effective at controlling the cancer, and …

This early-stage study tested whether adding a drug called olaparib to standard radiation therapy is safe and might help control advanced soft-tissue sarcomas that cannot be surgically removed. It involved 41 adults with these difficult-to-treat tumors. The main goal was to find …

This early-stage trial tested the safety of combining a new oral drug, navtemadlin, with standard radiation therapy before surgery for soft tissue sarcoma. The goal was to see if this combination could shrink tumors more effectively, potentially allowing surgeons to remove less h…

This study tested whether adding a new drug called ADI-PEG20 to standard chemotherapy could better control advanced soft tissue sarcomas and some other cancers. The new drug works by cutting off a nutrient some cancer cells need to survive, potentially making the chemotherapy mor…

This study tested a shorter, more intense schedule of radiation therapy given before surgery for soft tissue sarcomas in the arms, legs, or chest wall. The goal was to see if this approach could control the cancer as well as standard, longer radiation while being more convenient …

This study tested whether a new system for analyzing a patient's tumor genes could work fast enough to help doctors choose treatments. It involved 24 adults with advanced colorectal cancer or soft-tissue sarcoma. The main goal was to see if the complex process of gene sequencing …