SOFT-TISSUE SARCOMA

This early-phase trial tested whether adding the drug avelumab (compound 451238) to radiation therapy is safe for people with advanced soft-tissue sarcoma that has spread. Twelve adults with at least two tumors not curable by standard treatments took part. The main goal was to ch…

This study tested whether a combination of two chemotherapy drugs, nab-paclitaxel and gemcitabine, can stop or slow tumor growth in teenagers and young adults (ages 3 to 30) whose sarcoma (a type of bone or soft tissue cancer) had returned or was not responding to standard treatm…

This study tested whether adding the drug fluzoparil to radiation therapy before surgery is safe and effective for adults with soft tissue sarcoma in the arms, legs, or trunk. Fifty-two participants received either radiation alone or radiation plus fluzoparil. The main goal was t…

This early-stage trial tested whether adding the drug navtemadlin to standard radiation therapy before surgery is safe for people with soft tissue sarcoma. The goal was to shrink tumors and reduce the amount of healthy tissue removed during surgery. 39 participants were enrolled …

This study tested a shorter, higher-dose radiation course given before surgery for soft tissue sarcoma in the arms, legs, or chest wall. Researchers wanted to see if this approach was safe, feasible, and effective at controlling the tumor. The study included 35 adults with locali…

This study tested a two-step treatment for people with advanced soft tissue sarcoma that had stopped responding to standard therapy. First, a drug was injected into a tumor to attract immune cells. Then, that tumor was removed, and the immune cells were grown in a lab and infused…

This study looked at whether taking a break from the chemotherapy drug trabectedin (a drug holiday) is as safe and effective as continuing treatment without a break in people with advanced soft tissue sarcoma. Fifty-three adults whose cancer had not worsened after six cycles of t…

This early-phase study tested the safety of adding the drug olaparib to standard radiation therapy for people with advanced soft-tissue sarcoma that could not be removed by surgery. 41 adults took part. The main goals were to find the highest safe dose of olaparib and to see how …

This study tested a drug called ADI-PEG 20 combined with two chemotherapy drugs (gemcitabine and docetaxel) in 98 people with advanced soft tissue sarcoma, osteosarcoma, Ewing's sarcoma, or small cell lung cancer. The goal was to see if adding ADI-PEG 20, which starves cancer cel…

This early-phase trial tested a combination of two drugs—trabectedin and durvalumab—in 40 people with advanced soft-tissue sarcoma or ovarian cancer that had not responded to prior treatments. The main goal was to find the safest dose and check for early signs of tumor shrinkage.…

This study looked at how the anti-nausea medication aprepitant changes the amount of the chemotherapy drug ifosfamide in the blood of people with soft tissue sarcoma. 59 patients receiving doxorubicin and ifosfamide were followed for two treatment cycles. Blood samples were taken…

This pilot study tested whether it is possible to quickly analyze the genetic makeup of tumors from 24 adults with advanced colorectal cancer or soft tissue sarcoma. The main goal was to see how fast a detailed genetic report could be sent to doctors after receiving a sample. The…

This study looked at whether advanced genetic testing (called NGS) can be done quickly enough to help guide treatment choices for people with advanced soft-tissue sarcoma. About 600 adults with this rare cancer took part. The main goal was to see if the test results could be deli…