Can a protein predict chemo success in sarcoma?
NCT ID NCT04055753
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether a protein called TOPO2A can help predict if the chemotherapy drugs doxorubicin or Doxil will shrink tumors in people with soft tissue sarcoma. About 24 patients whose next treatment plan includes one of these drugs will provide tumor tissue for testing. Researchers will track how well the tumor responds and how long patients live, to see if TOPO2A levels match up with treatment success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Doxorubicin or Doxil (chemotherapy drugs)
What this could lead to
If successful, this could help doctors choose which patients are most likely to benefit from these chemotherapy drugs, personalizing treatment.
What could go wrong
This is a very small, early-phase study (24 people) focused on a biomarker, not a treatment itself. The biomarker may not reliably predict response, and results may not apply to all sarcoma types.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States