Can a Patient's own immune cells beat childhood cancers that Won't quit?

NCT ID NCT06566092

Ongoing Disease control Sponsor: Iovance Biotherapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a treatment made from a patient's own immune cells, called tumor-infiltrating lymphocytes (TIL). Doctors remove a piece of the tumor, grow the immune cells in a lab, and then infuse them back into the patient to attack the cancer. The study includes 40 children, teenagers, and young adults with solid tumors (like sarcoma or melanoma) that have returned or are not responding to standard treatments. The main goal is to see if the treatment is safe and tolerable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tumor-infiltrating lymphocytes (TIL)
What this could lead to: If it works, this could point toward a new treatment option for children and young adults with hard-to-treat solid tumors that have stopped responding to standard therapy.
What could go wrong: This is a very early (Phase 1) and small trial (40 people), so it is primarily testing safety, not effectiveness. The treatment may not shrink tumors, and side effects could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Ewing sarcoma melanoma primary brain neoplasm rhabdomyosarcoma sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EWING SARCOMA MELANOMA PRIMARY CENTRAL NERVOUS SYSTEM CARCINOMA RHABDOMYOSARCOMA SOFT TISSUE SARCOMA

Contacts and locations

Locations

Children's Hospital of Colorado

Aurora, Colorado, 80045, United States
Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Roswell Park Cancer Institute

Buffalo, New York, 14203, United States
Rutgers Cancer Institute

New Brunswick, New Jersey, 08901, United States

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