Virus and radiation combo takes aim at rare sarcomas
NCT ID NCT04599062
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether injecting a cancer-fighting virus (T-VEC) directly into tumors, along with standard radiation, is safe and tolerable for people with advanced soft tissue sarcoma. About 8 participants will receive the combination before surgery. The study primarily looks for side effects and how much tumor tissue dies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Talimogene laherparepvec (T-VEC), a modified herpes virus that attacks cancer cells, plus radiation therapy
What this could lead to
If successful, this combination could shrink sarcomas enough to allow complete surgical removal, potentially improving local control and survival.
What could go wrong
This is a very early, small Phase 1/2 trial with only 8 participants. The main goal is safety, not effectiveness. Side effects from the virus or radiation could be serious.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52242, United States