Radioactive drug takes aim at Hard-to-Treat cancers
NCT ID NCT07261631
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing a new radioactive drug (177Lu-DFC413) to see if it is safe and can shrink tumors in people with advanced solid cancers like pancreatic, lung, breast, colorectal, and sarcoma. About 180 adults whose cancer has progressed after standard treatments will receive the drug. The study also tests a companion imaging agent (68Ga-NNS309) to help see where the drug goes in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a radioactive drug (177Lu-DFC413) and a diagnostic imaging agent (68Ga-NNS309)
- What this could lead to
- If successful, this could point toward a new targeted radiation treatment for several hard-to-treat cancers.
- What could go wrong
- This is an early Phase 1 trial with only 180 participants, so the main goal is safety, not proof of effectiveness. The treatment may cause side effects or not shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Novartis Investigative Site
RECRUITINGMontreal, Quebec, H3T 1E2, Canada
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Novartis Investigative Site
RECRUITINGOdense C, 5000, Denmark
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Novartis Investigative Site
RECRUITINGVandœuvre-lès-Nancy, 54511, France
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Novartis Investigative Site
RECRUITINGEssen, 45147, Germany
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Novartis Investigative Site
RECRUITINGHaifa, 3109601, Israel
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Novartis Investigative Site
RECRUITINGTel Aviv, 6423906, Israel
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Novartis Investigative Site
RECRUITINGSingapore, 119228, Singapore
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Novartis Investigative Site
RECRUITINGSingapore, 168583, Singapore
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Other studies related to the condition(s) this trial covers.
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